Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 930915..931571 Replicon chromosome
Accession NZ_CP040182
Organism Serratia fonticola strain MS5

Toxin (Protein)


Gene name higB Uniprot ID A0A8I0CSE1
Locus tag FD644_RS04245 Protein ID WP_071682470.1
Coordinates 931248..931571 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4P8TYG0
Locus tag FD644_RS04240 Protein ID WP_071682469.1
Coordinates 930915..931205 (-) Length 97 a.a.

Genomic Context

FD644_RS04230FD644_RS04235FD644_RS04255FD644_RS04215FD644_RS04220FD644_RS04225FD644_RS04240FD644_RS04245FD644_RS04250
Location: 928885..929763 (879 bp)
Type: Others
Protein ID: WP_071682467.1
Location: 929942..930862 (921 bp)
Type: Others
Protein ID: WP_071682468.1
Location: 932741..934666 (1926 bp)
Type: Others
Protein ID: WP_071682472.1
Location: 926325..927053 (729 bp)
Type: Others
Protein ID: WP_071682464.1
Location: 927034..927795 (762 bp)
Type: Others
Protein ID: WP_071682465.1
Location: 927921..928742 (822 bp)
Type: Others
Protein ID: WP_071682466.1
Location: 930915..931205 (291 bp)
Type: Antitoxin
Protein ID: WP_071682469.1
Location: 931248..931571 (324 bp)
Type: Toxin
Protein ID: WP_071682470.1
Location: 931790..932506 (717 bp)
Type: Others
Protein ID: WP_071682471.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FD644_RS04215926325..927053-729WP_071682464.1RES family NAD+ phosphorylase-
FD644_RS04220927034..927795-762WP_071682465.1hypothetical protein-
FD644_RS04225927921..928742-822WP_071682466.1helix-turn-helix transcriptional regulator-
FD644_RS04230928885..929763+879WP_071682467.1helix-turn-helix domain-containing protein-
FD644_RS04235929942..930862+921WP_071682468.1L,D-transpeptidase family protein-
FD644_RS04240930915..931205-291WP_071682469.1helix-turn-helix domain-containing proteinAntitoxin
FD644_RS04245931248..931571-324WP_071682470.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FD644_RS04250931790..932506-717WP_071682471.1GntR family transcriptional regulator-
FD644_RS04255932741..934666+1926WP_071682472.1PTS 2-O-a-mannosyl-D-glycerate transporter subunit IIABC-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-80)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12376.19 Da        Isoelectric Point: 9.2975

>T125059 WP_071682470.1 NZ_CP040182:c931571-931248 [Serratia fonticola]
MEYFEFIETPVFSRQRETLLDDDSFRELQTHLLKYHSDGDTISKTGGCKKIRWNRPGMGKQGGVRVIYYVITRSGKLYLL
IAYPKNAKDDLTESEKAILKALTDKLN

Download         Length: 324 bp

>T125059 NZ_CP040182:c931571-931248 [Serratia fonticola]
ATGGAATACTTTGAGTTCATCGAAACCCCAGTTTTTAGCAGGCAACGCGAAACCCTATTAGACGATGATAGCTTTCGTGA
ACTACAAACCCACCTGTTAAAATATCACTCAGACGGCGATACTATAAGTAAAACAGGCGGTTGTAAAAAAATCCGATGGA
ACCGTCCAGGCATGGGGAAACAAGGTGGTGTAAGGGTTATCTATTACGTTATCACCCGCAGCGGCAAGCTTTACCTGCTG
ATTGCTTATCCTAAAAACGCCAAAGACGACTTAACCGAATCCGAGAAAGCGATACTTAAAGCGTTAACGGATAAACTGAA
TTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10900.57 Da        Isoelectric Point: 6.4836

>AT125059 WP_071682469.1 NZ_CP040182:c931205-930915 [Serratia fonticola]
VDKELFNDLVESMEQMVAIEKGEMQPARVHRHHIPNVKSLREASGMKQEEFAQAVGVSPSLVQSWEQNRRIPSGSSLKIL
LMIERHPTIVNDLLTI

Download         Length: 291 bp

>AT125059 NZ_CP040182:c931205-930915 [Serratia fonticola]
GTGGACAAAGAACTTTTTAACGATCTGGTCGAAAGCATGGAACAGATGGTCGCGATTGAAAAAGGCGAAATGCAGCCTGC
TCGTGTCCATCGCCATCATATCCCCAACGTGAAATCACTACGCGAAGCCAGCGGCATGAAGCAGGAAGAGTTTGCGCAGG
CGGTTGGAGTTAGTCCTTCCCTAGTGCAAAGTTGGGAACAAAATCGCCGAATACCCTCCGGCTCTTCACTCAAAATCTTG
CTGATGATTGAGCGCCACCCCACAATTGTTAACGATCTACTCACCATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A4P8TYG0

References