Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 286888..287450 Replicon chromosome
Accession NZ_CP040182
Organism Serratia fonticola strain MS5

Toxin (Protein)


Gene name higB Uniprot ID A0A8H9YD16
Locus tag FD644_RS01310 Protein ID WP_059199241.1
Coordinates 286888..287166 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8H9YCT7
Locus tag FD644_RS01315 Protein ID WP_071682694.1
Coordinates 287166..287450 (+) Length 95 a.a.

Genomic Context

FD644_RS01295FD644_RS01300FD644_RS01305FD644_RS01310FD644_RS01315FD644_RS01320FD644_RS01325FD644_RS01330
Location: 282716..283624 (909 bp)
Type: Others
Protein ID: WP_021181351.1
Location: 283633..285702 (2070 bp)
Type: Others
Protein ID: WP_071682692.1
Location: 285901..286620 (720 bp)
Type: Others
Protein ID: WP_071682693.1
Location: 286888..287166 (279 bp)
Type: Toxin
Protein ID: WP_059199241.1
Location: 287166..287450 (285 bp)
Type: Antitoxin
Protein ID: WP_071682694.1
Location: 288017..289933 (1917 bp)
Type: Others
Protein ID: WP_071682695.1
Location: 289996..291144 (1149 bp)
Type: Others
Protein ID: WP_071682696.1
Location: 291252..291866 (615 bp)
Type: Others
Protein ID: WP_175415600.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FD644_RS01295282716..283624+909WP_021181351.1glycine--tRNA ligase subunit alpha-
FD644_RS01300283633..285702+2070WP_071682692.1glycine--tRNA ligase subunit beta-
FD644_RS01305285901..286620+720WP_071682693.1DUF3053 domain-containing protein-
FD644_RS01310286888..287166+279WP_059199241.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FD644_RS01315287166..287450+285WP_071682694.1HigA family addiction module antidote proteinAntitoxin
FD644_RS01320288017..289933+1917WP_071682695.1PTS mannitol transporter subunit IICBA-
FD644_RS01325289996..291144+1149WP_071682696.1mannitol-1-phosphate 5-dehydrogenase-
FD644_RS01330291252..291866+615WP_175415600.1MltR family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10485.88 Da        Isoelectric Point: 9.8344

>T125053 WP_059199241.1 NZ_CP040182:286888-287166 [Serratia fonticola]
MIKSFKHKGLRQFFEKGSTAGINTQQIGKIRLRLGVIDAAKDISDINRPGYQLHPLSGDRAGQWSITVTGNWRITFEFIN
GDAYIVNYEDYH

Download         Length: 279 bp

>T125053 NZ_CP040182:286888-287166 [Serratia fonticola]
ATGATTAAGAGTTTTAAGCACAAGGGATTGCGACAGTTTTTTGAGAAAGGCTCTACGGCTGGCATCAATACTCAACAGAT
CGGTAAAATTCGTCTGAGGCTTGGTGTAATTGATGCAGCAAAGGACATCAGTGATATCAACCGCCCTGGCTATCAACTTC
ACCCATTGTCGGGTGACCGTGCCGGGCAGTGGTCAATAACCGTAACAGGCAACTGGCGCATCACGTTTGAATTTATCAAC
GGTGATGCCTATATCGTCAACTATGAGGATTATCACTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10137.86 Da        Isoelectric Point: 8.7051

>AT125053 WP_071682694.1 NZ_CP040182:287166-287450 [Serratia fonticola]
MAMHNPPHPGEIIAETLEELGVGIRVFARALMVAPSTAQRLVAGNAAVSPEMAVKLSIVLGSSPEFWLNLQDNYSLWIAK
KAVNTSQLKRLVTA

Download         Length: 285 bp

>AT125053 NZ_CP040182:287166-287450 [Serratia fonticola]
ATGGCTATGCATAACCCCCCGCATCCGGGCGAGATCATCGCTGAAACGCTGGAAGAACTGGGTGTTGGTATCCGCGTATT
TGCCAGGGCGTTGATGGTGGCACCCTCCACCGCACAGCGCTTGGTCGCAGGGAATGCGGCTGTTAGCCCTGAGATGGCGG
TGAAGTTGTCCATAGTGCTGGGCAGCTCCCCTGAATTCTGGCTAAACCTGCAGGATAATTACAGCCTGTGGATCGCCAAA
AAAGCAGTCAATACTTCGCAGCTAAAGCGTTTGGTTACCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References