Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 66617..67153 Replicon plasmid unnamed1
Accession NZ_CP040167
Organism Piscirickettsia salmonis strain Psal-104b

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1L6THY5
Locus tag Psal104b_RS16600 Protein ID WP_036772441.1
Coordinates 66617..66889 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag Psal104b_RS16605 Protein ID WP_032126795.1
Coordinates 66893..67153 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal104b_RS16580 (Psal104b_03291) 61809..62538 + 730 Protein_83 IS6 family transposase -
Psal104b_RS16585 (Psal104b_03293) 62581..63408 - 828 WP_048876208.1 IS30 family transposase -
Psal104b_RS16590 (Psal104b_03294) 64180..65244 + 1065 WP_174872554.1 IS91 family transposase -
Psal104b_RS16595 (Psal104b_03296) 65813..66541 - 729 WP_017375910.1 IS6 family transposase -
Psal104b_RS16600 (Psal104b_03297) 66617..66889 - 273 WP_036772441.1 Txe/YoeB family addiction module toxin Toxin
Psal104b_RS16605 (Psal104b_03298) 66893..67153 - 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Psal104b_RS16610 (Psal104b_03299) 67493..67657 + 165 Protein_89 IS6 family transposase -
Psal104b_RS18300 67644..67775 + 132 WP_257721319.1 hypothetical protein -
Psal104b_RS16615 (Psal104b_03300) 67943..68509 + 567 Protein_91 IS6 family transposase -
Psal104b_RS16620 (Psal104b_03301) 68512..68943 - 432 Protein_92 IS6 family transposase -
Psal104b_RS16625 (Psal104b_03302) 69332..69595 - 264 Protein_93 IS6 family transposase -
Psal104b_RS16630 (Psal104b_03303) 69675..70802 - 1128 WP_036772450.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..169619 169619
- inside IScluster/Tn - - 56195..86782 30587


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10785.31 Da        Isoelectric Point: 7.8926

>T125030 WP_036772441.1 NZ_CP040167:c66889-66617 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRMPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
ISACRYHYDQ

Download         Length: 273 bp

>T125030 NZ_CP040167:c66889-66617 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
GCTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCATGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTTCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT125030 WP_032126795.1 NZ_CP040167:c67153-66893 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT125030 NZ_CP040167:c67153-66893 [Piscirickettsia salmonis]
ATGCTACGAGATAACATCAATGCTACGGCAGCACGGGATAATTTTAAGAGTACCTGTGATACAGTGTGTGAAAACAATGC
TCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGTATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6THY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References