Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4825689..4826101 Replicon chromosome
Accession NZ_CP040107
Organism Escherichia coli O157:H7 strain MB9-1

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag FDZ86_RS24240 Protein ID WP_000132630.1
Coordinates 4825760..4826101 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4825689..4825765 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDZ86_RS24230 4822316..4823785 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
FDZ86_RS24235 4823785..4825539 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4825689..4825765 - 77 NuclAT_15 - Antitoxin
- 4825689..4825765 - 77 NuclAT_15 - Antitoxin
- 4825689..4825765 - 77 NuclAT_15 - Antitoxin
- 4825689..4825765 - 77 NuclAT_15 - Antitoxin
- 4825689..4825765 - 77 NuclAT_16 - Antitoxin
- 4825689..4825765 - 77 NuclAT_16 - Antitoxin
- 4825689..4825765 - 77 NuclAT_16 - Antitoxin
- 4825689..4825765 - 77 NuclAT_16 - Antitoxin
FDZ86_RS24240 4825760..4826101 + 342 WP_000132630.1 endoribonuclease SymE Toxin
FDZ86_RS24245 4826148..4827311 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
FDZ86_RS24250 4827359..4828240 - 882 WP_001304007.1 DUF262 domain-containing protein -
FDZ86_RS24255 4828337..4828501 - 165 WP_000394274.1 DUF1127 domain-containing protein -
FDZ86_RS24260 4828678..4830090 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4817888..4839131 21243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T124983 WP_000132630.1 NZ_CP040107:4825760-4826101 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T124983 NZ_CP040107:4825760-4826101 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT124983 NZ_CP040107:c4825765-4825689 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References