Detailed information of TA system TA124945

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 636781..637357
• Replicon: chromosome
• Accession: NZ_CP040098
• Organism: Desulfoglaeba alkanexedens ALDC

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FDQ92_RS03145
• Protein ID: WP_137423238.1
• Coordinates: 636781..637059 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: FDQ92_RS03150
• Protein ID: WP_137423239.1
• Coordinates: 637070..637357 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDQ92_RS03125	633044..633514	+	471	WP_137423235.1	nuclear transport factor 2 family protein	-
FDQ92_RS03130	633662..635710	+	2049	WP_211341349.1	copper-translocating P-type ATPase	-
FDQ92_RS03135	635840..636484	+	645	WP_137423236.1	hypothetical protein	-
FDQ92_RS03140	636530..636733	+	204	WP_137423237.1	hypothetical protein	-
FDQ92_RS03145	636781..637059	+	279	WP_137423238.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FDQ92_RS03150	637070..637357	+	288	WP_137423239.1	HigA family addiction module antidote protein	Antitoxin
FDQ92_RS03155	637456..637641	+	186	WP_137423240.1	hypothetical protein	-
FDQ92_RS15140	637629..637853	+	225	WP_170180157.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FDQ92_RS03165	638214..638657	-	444	WP_137423241.1	Hsp20/alpha crystallin family protein	-
FDQ92_RS03170	639009..639662	+	654	WP_137423242.1	lactate utilization protein	-
FDQ92_RS03175	639691..640608	+	918	WP_137423243.1	FAD-dependent oxidoreductase	-
FDQ92_RS03180	640605..641354	+	750	WP_137423244.1	HAD family hydrolase	-
FDQ92_RS03185	641388..642332	-	945	WP_137423245.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	625998..637641	11643
	-	inside	Integron	-	-	633044..637641	4597

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-91)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10318.75 Da
• Isoelectric Point: 10.2284

>T124945 WP_137423238.1 NZ_CP040098:636781-637059 [Desulfoglaeba alkanexedens ALDC]
MIRSFKHKGLACFFQTGSTAGIQSAYAKKLRLILGRLHAASSPQDMNLPGLRLHELSGKRAGTWAVDVSGNWRITFKFSG
NDTEFVNYEDYH

Nucleotide

• Length: 279 bp

>T124945 NZ_CP040098:636781-637059 [Desulfoglaeba alkanexedens ALDC]
ATGATCCGGAGCTTCAAGCACAAGGGACTGGCCTGTTTCTTTCAAACTGGTAGTACTGCTGGAATCCAATCAGCTTACGC
AAAGAAGCTCCGTCTTATCCTCGGTCGGCTTCATGCCGCTTCCAGCCCTCAGGACATGAATTTGCCGGGGCTGCGGCTGC
ATGAGCTGAGCGGAAAGCGAGCAGGTACCTGGGCCGTGGACGTCAGTGGAAACTGGCGGATTACATTTAAGTTCTCAGGC
AATGACACCGAGTTTGTTAACTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10507.13 Da
• Isoelectric Point: 6.7171

>AT124945 WP_137423239.1 NZ_CP040098:637070-637357 [Desulfoglaeba alkanexedens ALDC]
MLMHNPPHPGEIIRELCLEPLGISVTEAAKALGVSRKTLSAILNGRAGISPEMAVRLSIAFDTSAESWMNQQVQFDLWNA
EQHRKELKVERISAA

Nucleotide

• Length: 288 bp

>AT124945 NZ_CP040098:637070-637357 [Desulfoglaeba alkanexedens ALDC]
ATGCTTATGCACAATCCTCCCCATCCCGGCGAAATCATTAGAGAGCTCTGCCTGGAGCCGCTGGGTATCTCCGTCACCGA
AGCTGCCAAGGCTCTTGGGGTGAGCCGGAAGACCCTGAGTGCAATTCTAAATGGTCGAGCAGGCATCAGCCCGGAGATGG
CCGTACGACTTTCAATTGCCTTTGATACGTCGGCCGAAAGCTGGATGAACCAACAAGTCCAATTTGATCTATGGAATGCA
GAACAGCATCGGAAGGAACTGAAGGTCGAGCGAATTTCTGCTGCATAA