Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3967921..3968605 Replicon chromosome
Accession NZ_CP040095
Organism Pantoea sp. SO10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FCN45_RS18395 Protein ID WP_137386711.1
Coordinates 3968273..3968605 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FCN45_RS18390 Protein ID WP_101762746.1
Coordinates 3967921..3968253 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCN45_RS18375 3964723..3966402 - 1680 WP_137386709.1 potassium-transporting ATPase subunit KdpA -
FCN45_RS18380 3966402..3966491 - 90 WP_081113208.1 K(+)-transporting ATPase subunit F -
FCN45_RS18385 3966601..3967764 - 1164 WP_137386710.1 HD-GYP domain-containing protein -
FCN45_RS18390 3967921..3968253 - 333 WP_101762746.1 HigA family addiction module antidote protein Antitoxin
FCN45_RS18395 3968273..3968605 - 333 WP_137386711.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FCN45_RS18400 3968729..3970120 - 1392 WP_137386712.1 MFS transporter -
FCN45_RS18405 3970532..3971446 + 915 WP_137386713.1 sugar ABC transporter substrate-binding protein -
FCN45_RS18410 3971529..3972023 - 495 WP_137386714.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13075.05 Da        Isoelectric Point: 10.0668

>T124938 WP_137386711.1 NZ_CP040095:c3968605-3968273 [Pantoea sp. SO10]
MKGSIHSFRDDWLRLFFVYATPHKHIPAMIESVLARKLDIIHAATSHHDLRSPPGNRFEALRPPLLGYYSIRINEQYRLI
FQWVNGTARDFYLDPHTYRKHRYQPLVANC

Download         Length: 333 bp

>T124938 NZ_CP040095:c3968605-3968273 [Pantoea sp. SO10]
ATGAAGGGTTCAATTCACAGTTTCAGGGACGATTGGCTGCGATTATTTTTTGTTTATGCAACACCGCATAAGCATATCCC
GGCCATGATTGAGTCCGTATTGGCGCGCAAGCTCGACATCATCCATGCCGCAACATCGCATCATGATTTGCGTTCACCAC
CGGGTAATCGCTTTGAGGCCTTAAGACCTCCGCTATTGGGATATTATTCAATACGGATAAATGAGCAGTATCGACTAATT
TTTCAATGGGTTAATGGCACGGCAAGAGATTTCTATCTCGATCCACACACTTATCGTAAACACCGCTACCAGCCACTTGT
GGCCAACTGCTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12618.41 Da        Isoelectric Point: 5.7065

>AT124938 WP_101762746.1 NZ_CP040095:c3968253-3967921 [Pantoea sp. SO10]
MKQAMRKPTSVGDVLQYEFLEPLNLKVNDLAEMLNVHRNTVSALVNNNRKLTTEMAYRLAAVFDTSVDFWLNLQRHLDLW
EVENDARTQEELSRVTPLSAFLAQRSAVVA

Download         Length: 333 bp

>AT124938 NZ_CP040095:c3968253-3967921 [Pantoea sp. SO10]
ATGAAACAGGCGATGCGTAAACCGACCAGCGTTGGCGATGTTTTGCAGTACGAGTTCCTCGAGCCGCTTAACCTCAAAGT
GAATGACCTGGCAGAGATGTTGAACGTGCACCGCAATACAGTCAGTGCATTGGTGAATAACAACCGTAAACTGACCACCG
AAATGGCCTATAGGCTGGCAGCTGTTTTCGATACTTCAGTCGATTTTTGGCTGAATCTGCAGCGCCATTTGGATCTATGG
GAAGTGGAAAACGATGCCAGAACACAGGAAGAGTTGAGCAGGGTAACGCCGTTAAGTGCCTTTCTGGCGCAGCGTTCAGC
GGTTGTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References