Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 909444..910168 Replicon chromosome
Accession NZ_CP040095
Organism Pantoea sp. SO10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FCN45_RS04135 Protein ID WP_101762563.1
Coordinates 909857..910168 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FCN45_RS04130 Protein ID WP_137386846.1
Coordinates 909444..909860 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCN45_RS04110 904967..906223 + 1257 WP_137385214.1 allantoate amidohydrolase -
FCN45_RS04115 906233..906727 + 495 WP_137385215.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
FCN45_RS04120 906724..907059 + 336 WP_101762537.1 hydroxyisourate hydrolase -
FCN45_RS04125 907202..909400 + 2199 WP_137385216.1 catalase/peroxidase HPI -
FCN45_RS04130 909444..909860 - 417 WP_137386846.1 transcriptional regulator Antitoxin
FCN45_RS04135 909857..910168 - 312 WP_101762563.1 type II toxin-antitoxin system HigB family toxin Toxin
FCN45_RS04140 910301..911071 - 771 WP_137385217.1 amidohydrolase -
FCN45_RS04145 911059..912219 - 1161 WP_101762533.1 pyridoxal phosphate-dependent aminotransferase -
FCN45_RS04150 912351..912965 + 615 WP_101762532.1 methylthioribulose 1-phosphate dehydratase -
FCN45_RS04155 912962..913645 + 684 WP_137385218.1 acireductone synthase -
FCN45_RS04160 913647..914189 + 543 WP_101762530.1 acireductone dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12169.89 Da        Isoelectric Point: 10.0567

>T124931 WP_101762563.1 NZ_CP040095:c910168-909857 [Pantoea sp. SO10]
MHVISRKVFTEATRSFPNDAAALDATYRTLNGNDFADPDALRAFFPSLDRMKYRAKWWVINVGGNNLRVMFFADFIAQRI
FIKHVVTHAEYDKWVKHYRENKE

Download         Length: 312 bp

>T124931 NZ_CP040095:c910168-909857 [Pantoea sp. SO10]
ATGCATGTTATCTCAAGGAAAGTGTTTACAGAAGCGACACGGAGTTTTCCAAATGATGCAGCAGCATTGGATGCAACTTA
TCGAACTTTAAATGGCAACGATTTTGCCGATCCAGATGCGCTCAGAGCCTTTTTTCCAAGTCTTGACCGAATGAAATACC
GGGCGAAATGGTGGGTGATTAACGTGGGTGGAAATAATCTCAGAGTGATGTTTTTTGCTGATTTTATAGCCCAACGAATC
TTCATTAAACACGTTGTAACGCATGCCGAGTATGACAAATGGGTAAAGCATTATCGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15391.53 Da        Isoelectric Point: 5.6263

>AT124931 WP_137386846.1 NZ_CP040095:c909860-909444 [Pantoea sp. SO10]
MIAEAIQASNNLIKAVPLLGGSNAKADYEQALELVEYLIEHQPDHPLIEMLTDKVAKYEDSAPEFAAFNARVTALPGGVA
LLRVLMDQHNLNQSSFVNEIGQRSYVNRILKGERSLTDKHKAALAKRFNLPFEAFRED

Download         Length: 417 bp

>AT124931 NZ_CP040095:c909860-909444 [Pantoea sp. SO10]
ATGATCGCCGAAGCCATCCAGGCCAGCAACAATCTGATTAAAGCCGTCCCGCTGCTGGGCGGAAGTAACGCGAAAGCTGA
TTATGAGCAGGCGTTAGAACTGGTGGAGTATCTGATTGAACATCAACCTGATCATCCGCTGATTGAAATGCTCACCGATA
AAGTGGCGAAATATGAAGATAGTGCGCCGGAATTTGCCGCGTTCAACGCGCGTGTCACTGCATTACCTGGCGGTGTCGCG
TTACTGCGGGTGTTGATGGATCAACATAATCTCAATCAGTCATCCTTCGTGAATGAAATTGGTCAGCGTTCTTATGTAAA
CCGAATTTTGAAAGGAGAACGTTCGTTGACAGACAAACACAAAGCCGCGCTGGCTAAACGTTTTAACCTGCCTTTCGAAG
CATTTCGCGAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References