Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 481448..482099 Replicon chromosome
Accession NZ_CP040095
Organism Pantoea sp. SO10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FCN45_RS02130 Protein ID WP_137385032.1
Coordinates 481448..481813 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FCN45_RS02135 Protein ID WP_137385033.1
Coordinates 481800..482099 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCN45_RS02110 477413..478123 - 711 WP_137385029.1 5-oxoprolinase subunit PxpB -
FCN45_RS02115 478126..478965 - 840 WP_137385030.1 transporter substrate-binding domain-containing protein -
FCN45_RS02120 479236..480156 + 921 WP_137385031.1 DMT family transporter -
FCN45_RS02125 480291..480986 - 696 WP_101762304.1 RraA family protein -
FCN45_RS02130 481448..481813 + 366 WP_137385032.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FCN45_RS02135 481800..482099 + 300 WP_137385033.1 helix-turn-helix transcriptional regulator Antitoxin
FCN45_RS02145 482372..482950 - 579 WP_101762303.1 transcriptional regulator -
FCN45_RS02150 483017..484717 - 1701 WP_137385034.1 protein-disulfide reductase DsbD -
FCN45_RS02155 484801..486102 - 1302 WP_137385035.1 anaerobic C4-dicarboxylate transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-110)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13855.94 Da        Isoelectric Point: 5.2356

>T124930 WP_137385032.1 NZ_CP040095:481448-481813 [Pantoea sp. SO10]
MNSWEVEITLLFAAWLQEQDDEMVEDVLSSLELLKVFGPMLGRPDVDTVTGSRFANMKELRVQSNGRPIRAFFAFDPVRK
AIVLCAGDKTGVNQKRFYQSMIKLADKEYKQHLEELTNAKT

Download         Length: 366 bp

>T124930 NZ_CP040095:481448-481813 [Pantoea sp. SO10]
TTGAACAGTTGGGAAGTCGAAATTACTTTGCTCTTCGCAGCATGGCTGCAAGAACAAGATGACGAAATGGTTGAAGATGT
GTTGTCGAGTCTCGAACTGCTGAAAGTGTTTGGCCCAATGTTGGGGCGACCGGATGTCGATACCGTCACCGGCTCTCGTT
TTGCCAACATGAAGGAACTTCGCGTTCAAAGCAATGGAAGGCCTATTCGCGCATTTTTCGCGTTTGATCCCGTGAGGAAG
GCTATCGTGCTGTGTGCGGGGGATAAAACTGGAGTGAATCAGAAGCGTTTCTACCAATCGATGATCAAACTAGCCGATAA
AGAGTACAAGCAGCATCTGGAGGAACTAACCAATGCAAAAACTTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11159.96 Da        Isoelectric Point: 6.4051

>AT124930 WP_137385033.1 NZ_CP040095:481800-482099 [Pantoea sp. SO10]
MQKLEELIAQRSPESQERIKSKADQKIMEIRLRQLREELELSQVQLAEKMGISQPAIAAIEARGDEIKLSSLKKYVEALG
GKLSLNVELPTGDGRIFQI

Download         Length: 300 bp

>AT124930 NZ_CP040095:481800-482099 [Pantoea sp. SO10]
ATGCAAAAACTTGAAGAATTGATTGCGCAGCGTTCCCCTGAATCTCAGGAGCGCATTAAAAGTAAGGCTGATCAAAAAAT
CATGGAAATCCGCCTGCGTCAGTTGCGTGAGGAGCTGGAACTTTCACAGGTGCAGCTGGCTGAAAAGATGGGTATCTCGC
AACCTGCTATCGCAGCGATTGAGGCGCGAGGTGACGAGATAAAACTTTCCAGCCTGAAAAAATATGTAGAAGCGTTAGGC
GGTAAGTTGAGTCTGAATGTTGAACTTCCCACCGGAGATGGTCGGATATTTCAGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References