Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 447258..447866 Replicon chromosome
Accession NZ_CP040094
Organism Nostoc sp. TCL240-02

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FBB35_RS02000 Protein ID WP_174708257.1
Coordinates 447582..447866 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FBB35_RS01995 Protein ID WP_174708256.1
Coordinates 447258..447566 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FBB35_RS01985 442539..443363 - 825 WP_174708255.1 Uma2 family endonuclease -
FBB35_RS01990 443513..447247 + 3735 WP_174713494.1 HEAT repeat domain-containing protein -
FBB35_RS01995 447258..447566 - 309 WP_174708256.1 HigA family addiction module antidote protein Antitoxin
FBB35_RS02000 447582..447866 - 285 WP_174708257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FBB35_RS02005 448267..449352 + 1086 WP_174708258.1 bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada -
FBB35_RS02010 449336..449974 + 639 WP_174708259.1 DNA-3-methyladenine glycosylase 2 family protein -
FBB35_RS02015 450071..451069 + 999 WP_174708260.1 DMT family transporter -
FBB35_RS02020 451342..452220 - 879 WP_174708261.1 diaminopimelate epimerase -
FBB35_RS02025 452290..452514 + 225 WP_174708262.1 RNA chaperone Hfq -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10878.45 Da        Isoelectric Point: 7.9985

>T124925 WP_174708257.1 NZ_CP040094:c447866-447582 [Nostoc sp. TCL240-02]
VIVSFKSEETKLIFDGFISSQYPPNIQKTALRKLLILDAATSINDLRVPPGNRLEKLLGNRKGQYSIRINNQWRICFVWT
DENNVSEVEIVDYH

Download         Length: 285 bp

>T124925 NZ_CP040094:c447866-447582 [Nostoc sp. TCL240-02]
GTGATTGTTAGTTTTAAATCTGAAGAGACAAAGCTTATCTTTGACGGCTTTATATCCTCTCAGTATCCTCCCAATATCCA
AAAAACTGCTTTACGAAAACTGCTTATTCTTGACGCTGCAACATCAATTAATGATTTACGCGTTCCACCTGGTAATCGTT
TAGAAAAGCTACTTGGCAATAGGAAAGGGCAATACAGTATTCGTATTAATAATCAATGGCGAATCTGCTTTGTTTGGACG
GATGAGAACAATGTTTCGGAAGTTGAAATAGTAGATTATCACTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11820.36 Da        Isoelectric Point: 5.7926

>AT124925 WP_174708256.1 NZ_CP040094:c447566-447258 [Nostoc sp. TCL240-02]
MNNNRLPNIYPGEILQLEFLEPLNITPYRLSKDIGVAQTRISEILSGKRTITADTALRLSRYFGNSAQFWLNLQTQYDIR
QALEENAEVYNQIPTFSFHNIT

Download         Length: 309 bp

>AT124925 NZ_CP040094:c447566-447258 [Nostoc sp. TCL240-02]
ATGAACAACAACCGTTTGCCAAATATTTACCCTGGAGAAATCCTACAACTAGAATTTTTAGAGCCACTAAATATCACCCC
TTATCGATTAAGCAAAGATATAGGTGTAGCTCAGACAAGAATTAGTGAAATTTTATCTGGAAAACGTACTATTACAGCAG
ATACAGCTTTGCGTTTATCTCGCTATTTTGGTAACAGCGCTCAGTTTTGGTTAAATTTACAAACGCAATACGATATACGT
CAAGCTCTTGAAGAAAATGCAGAAGTTTATAATCAAATACCTACATTTTCGTTTCATAATATAACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References