Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 447258..447866 Replicon chromosome
Accession NZ_CP040094
Organism Nostoc sp. TCL240-02

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FBB35_RS02000 Protein ID WP_174708257.1
Coordinates 447582..447866 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FBB35_RS01995 Protein ID WP_174708256.1
Coordinates 447258..447566 (-) Length 103 a.a.

Genomic Context

FBB35_RS01990FBB35_RS02005FBB35_RS02010FBB35_RS02015FBB35_RS02025FBB35_RS01985FBB35_RS01995FBB35_RS02000FBB35_RS02020
Location: 443513..447247 (3735 bp)
Type: Others
Protein ID: WP_174713494.1
Location: 448267..449352 (1086 bp)
Type: Others
Protein ID: WP_174708258.1
Location: 449336..449974 (639 bp)
Type: Others
Protein ID: WP_174708259.1
Location: 450071..451069 (999 bp)
Type: Others
Protein ID: WP_174708260.1
Location: 452290..452514 (225 bp)
Type: Others
Protein ID: WP_174708262.1
Location: 442539..443363 (825 bp)
Type: Others
Protein ID: WP_174708255.1
Location: 447258..447566 (309 bp)
Type: Antitoxin
Protein ID: WP_174708256.1
Location: 447582..447866 (285 bp)
Type: Toxin
Protein ID: WP_174708257.1
Location: 451342..452220 (879 bp)
Type: Others
Protein ID: WP_174708261.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FBB35_RS01985442539..443363-825WP_174708255.1Uma2 family endonuclease-
FBB35_RS01990443513..447247+3735WP_174713494.1HEAT repeat domain-containing protein-
FBB35_RS01995447258..447566-309WP_174708256.1HigA family addiction module antidote proteinAntitoxin
FBB35_RS02000447582..447866-285WP_174708257.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FBB35_RS02005448267..449352+1086WP_174708258.1bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada-
FBB35_RS02010449336..449974+639WP_174708259.1DNA-3-methyladenine glycosylase 2 family protein-
FBB35_RS02015450071..451069+999WP_174708260.1DMT family transporter-
FBB35_RS02020451342..452220-879WP_174708261.1diaminopimelate epimerase-
FBB35_RS02025452290..452514+225WP_174708262.1RNA chaperone Hfq-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10878.45 Da        Isoelectric Point: 7.9985

>T124925 WP_174708257.1 NZ_CP040094:c447866-447582 [Nostoc sp. TCL240-02]
VIVSFKSEETKLIFDGFISSQYPPNIQKTALRKLLILDAATSINDLRVPPGNRLEKLLGNRKGQYSIRINNQWRICFVWT
DENNVSEVEIVDYH

Download         Length: 285 bp

>T124925 NZ_CP040094:c447866-447582 [Nostoc sp. TCL240-02]
GTGATTGTTAGTTTTAAATCTGAAGAGACAAAGCTTATCTTTGACGGCTTTATATCCTCTCAGTATCCTCCCAATATCCA
AAAAACTGCTTTACGAAAACTGCTTATTCTTGACGCTGCAACATCAATTAATGATTTACGCGTTCCACCTGGTAATCGTT
TAGAAAAGCTACTTGGCAATAGGAAAGGGCAATACAGTATTCGTATTAATAATCAATGGCGAATCTGCTTTGTTTGGACG
GATGAGAACAATGTTTCGGAAGTTGAAATAGTAGATTATCACTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11820.36 Da        Isoelectric Point: 5.7926

>AT124925 WP_174708256.1 NZ_CP040094:c447566-447258 [Nostoc sp. TCL240-02]
MNNNRLPNIYPGEILQLEFLEPLNITPYRLSKDIGVAQTRISEILSGKRTITADTALRLSRYFGNSAQFWLNLQTQYDIR
QALEENAEVYNQIPTFSFHNIT

Download         Length: 309 bp

>AT124925 NZ_CP040094:c447566-447258 [Nostoc sp. TCL240-02]
ATGAACAACAACCGTTTGCCAAATATTTACCCTGGAGAAATCCTACAACTAGAATTTTTAGAGCCACTAAATATCACCCC
TTATCGATTAAGCAAAGATATAGGTGTAGCTCAGACAAGAATTAGTGAAATTTTATCTGGAAAACGTACTATTACAGCAG
ATACAGCTTTGCGTTTATCTCGCTATTTTGGTAACAGCGCTCAGTTTTGGTTAAATTTACAAACGCAATACGATATACGT
CAAGCTCTTGAAGAAAATGCAGAAGTTTATAATCAAATACCTACATTTTCGTTTCATAATATAACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References