Detailed information of TA system TA124894

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2651..3299
• Replicon: plasmid unnamed3
• Accession: NZ_CP040083
• Organism: Acinetobacter baumannii strain SP304

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FDM99_RS18360
• Protein ID: WP_137345285.1
• Coordinates: 2946..3299 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FDM99_RS18355
• Protein ID: WP_137345284.1
• Coordinates: 2651..2953 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDM99_RS18495	869..1051	+	183	WP_171476421.1	hypothetical protein	-
FDM99_RS18340	1370..1863	-	494	Protein_1	SMI1/KNR4 family protein	-
FDM99_RS18345	1920..2275	-	356	Protein_2	SEL1-like repeat protein	-
FDM99_RS18350	2450..2658	-	209	Protein_3	hypothetical protein	-
FDM99_RS18355	2651..2953	-	303	WP_137345284.1	XRE family transcriptional regulator	Antitoxin
FDM99_RS18360	2946..3299	-	354	WP_137345285.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FDM99_RS18365	3849..4239	-	391	Protein_6	tautomerase family protein	-
FDM99_RS18370	4413..4730	-	318	WP_032040166.1	hypothetical protein	-
FDM99_RS18375	4935..5126	-	192	WP_000102616.1	hypothetical protein	-
FDM99_RS18385	6494..7417	+	924	WP_000845851.1	replication initiation protein RepM	-
FDM99_RS18390	7485..8033	+	549	WP_137345286.1	plasmid replication DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..9185	9185

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-81)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13318.21 Da
• Isoelectric Point: 5.1116

>T124894 WP_137345285.1 NZ_CP040083:c3299-2946 [Acinetobacter baumannii]
MWTVITTDLFNEWLVQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKSFYKEMLDIADQQYELHLSTLGDQSNG

Nucleotide

• Length: 354 bp

>T124894 NZ_CP040083:c3299-2946 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGTACAGCAAGATGAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ACATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCATTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAGCTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAACTTCA
TCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11178.08 Da
• Isoelectric Point: 9.6900

>AT124894 WP_137345284.1 NZ_CP040083:c2953-2651 [Acinetobacter baumannii]
MAKTLQKLLASRSPESQARIQKMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Nucleotide

• Length: 303 bp

>AT124894 NZ_CP040083:c2953-2651 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAAAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCGTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTTAATGTCTAA