Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 6353..7004 Replicon plasmid unnamed1
Accession NZ_CP040081
Organism Acinetobacter baumannii strain SP304

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FDM99_RS18230 Protein ID WP_137345282.1
Coordinates 6353..6709 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FDM99_RS18235 Protein ID WP_001140621.1
Coordinates 6702..7004 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDM99_RS18200 1654..2052 + 399 Protein_2 tautomerase family protein -
FDM99_RS18215 3626..4550 + 925 Protein_3 replication initiation protein RepM -
FDM99_RS18220 4618..5163 + 546 WP_000736775.1 plasmid replication DNA-binding protein -
FDM99_RS18225 5501..5816 + 316 Protein_5 hypothetical protein -
FDM99_RS18230 6353..6709 + 357 WP_137345282.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FDM99_RS18235 6702..7004 + 303 WP_001140621.1 XRE family transcriptional regulator Antitoxin
FDM99_RS18240 6997..7206 + 210 WP_000069474.1 hypothetical protein -
FDM99_RS18245 7381..7899 + 519 WP_137345283.1 sel1 repeat family protein -
FDM99_RS18250 7937..8449 + 513 WP_001089573.1 SMI1/KNR4 family protein -
FDM99_RS18255 9247..9636 + 390 WP_032040164.1 tautomerase family protein -
FDM99_RS18260 9679..9870 - 192 WP_000102616.1 hypothetical protein -
FDM99_RS18185 11253..11928 + 676 Protein_13 replication initiation protein RepM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11933 11933


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13500.47 Da        Isoelectric Point: 5.7034

>T124892 WP_137345282.1 NZ_CP040081:6353-6709 [Acinetobacter baumannii]
MWTVITTDLFNEWLVQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSIFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYELHLSTLGDQSNG

Download         Length: 357 bp

>T124892 NZ_CP040081:6353-6709 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGTACAGCAAGATGAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCATTTTTACCA
ACATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCATTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAACT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11179.02 Da        Isoelectric Point: 7.3198

>AT124892 WP_001140621.1 NZ_CP040081:6702-7004 [Acinetobacter baumannii]
MAKTLQELLASRSPESQARIQKMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT124892 NZ_CP040081:6702-7004 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCGTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTTAATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References