Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 555744..556337 Replicon chromosome
Accession NZ_CP040078
Organism Burkholderia sp. DHOD12

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FAZ95_RS24500 Protein ID WP_137335116.1
Coordinates 555744..556022 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FAZ95_RS24505 Protein ID WP_137335117.1
Coordinates 556035..556337 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FAZ95_RS24470 550853..551563 - 711 WP_137335110.1 hypothetical protein -
FAZ95_RS24475 552139..552384 + 246 WP_137335111.1 H-NS histone family protein -
FAZ95_RS24480 552577..553233 - 657 WP_137335112.1 5,6-dimethylbenzimidazole synthase -
FAZ95_RS24485 553217..554518 - 1302 WP_137335113.1 cobyrinate a,c-diamide synthase -
FAZ95_RS24490 554522..555124 - 603 WP_137335114.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
FAZ95_RS24495 555121..555528 - 408 WP_137335115.1 cobalamin biosynthesis protein -
FAZ95_RS24500 555744..556022 + 279 WP_137335116.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FAZ95_RS24505 556035..556337 + 303 WP_137335117.1 HigA family addiction module antidote protein Antitoxin
FAZ95_RS24510 556832..557893 + 1062 WP_137335118.1 HoxN/HupN/NixA family nickel/cobalt transporter -
FAZ95_RS24515 557909..558985 + 1077 WP_137335119.1 cobalamin biosynthesis protein CobW -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10553.20 Da        Isoelectric Point: 9.2502

>T124886 WP_137335116.1 NZ_CP040078:555744-556022 [Burkholderia sp. DHOD12]
MIKSFRCKDTEALYAGKSPKRFRAIEAVAIRKLQMLEAAKELKDLRSPPGNQLEALKGDRRGQCSIRINGQWRLCFVWTD
DGATEIEIVDYH

Download         Length: 279 bp

>T124886 NZ_CP040078:555744-556022 [Burkholderia sp. DHOD12]
ATGATTAAGTCCTTCCGATGCAAAGACACCGAAGCCCTTTACGCCGGCAAATCGCCGAAACGCTTTCGTGCAATTGAGGC
GGTTGCGATACGCAAGCTTCAGATGCTGGAGGCGGCCAAGGAACTGAAAGATCTACGCTCACCGCCTGGCAACCAACTCG
AGGCGCTCAAAGGCGACCGGCGCGGCCAGTGCAGCATCCGCATCAACGGTCAATGGCGTTTGTGTTTCGTATGGACGGAC
GACGGTGCGACCGAGATCGAAATCGTCGACTACCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11443.18 Da        Isoelectric Point: 7.3172

>AT124886 WP_137335117.1 NZ_CP040078:556035-556337 [Burkholderia sp. DHOD12]
MVKNGMRPVHPGEILREEYLVPLEMSVNALALALNVPATRLHEIVKERRGITADTAYRLARYFDSTPEFWLNLQAAYDLK
TLSTRAEIDRKVEPREAAHP

Download         Length: 303 bp

>AT124886 NZ_CP040078:556035-556337 [Burkholderia sp. DHOD12]
ATGGTCAAGAACGGAATGCGCCCGGTACACCCGGGCGAAATCCTGCGGGAGGAATATCTGGTTCCGCTGGAAATGAGCGT
GAATGCGCTCGCGCTGGCACTGAACGTGCCAGCAACGCGACTTCACGAGATCGTGAAGGAACGGCGTGGCATCACTGCCG
ACACCGCGTACCGGCTTGCGCGTTACTTCGATTCGACGCCCGAATTCTGGCTGAACCTGCAAGCCGCGTATGACCTTAAG
ACGCTGTCGACGCGGGCCGAGATTGATCGCAAGGTCGAGCCTCGCGAGGCAGCGCATCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References