Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 3663473..3664128 Replicon chromosome
Accession NZ_CP040077
Organism Burkholderia sp. DHOD12

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FAZ95_RS16775 Protein ID WP_137333475.1
Coordinates 3663473..3663817 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FAZ95_RS16780 Protein ID WP_137333476.1
Coordinates 3663814..3664128 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FAZ95_RS16755 3659598..3660881 + 1284 WP_137333472.1 glutamate-1-semialdehyde 2,1-aminomutase -
FAZ95_RS16760 3660915..3662048 + 1134 WP_137333473.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
FAZ95_RS16765 3662067..3662696 + 630 WP_137333474.1 riboflavin synthase -
FAZ95_RS16770 3662848..3663345 - 498 WP_137334595.1 hypothetical protein -
FAZ95_RS16775 3663473..3663817 + 345 WP_137333475.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FAZ95_RS16780 3663814..3664128 + 315 WP_137333476.1 transcriptional regulator Antitoxin
FAZ95_RS16785 3664520..3664711 + 192 WP_137334596.1 hypothetical protein -
FAZ95_RS16790 3664772..3665521 - 750 WP_137333477.1 creatininase family protein -
FAZ95_RS16795 3665680..3666615 - 936 WP_137333478.1 LysR family transcriptional regulator -
FAZ95_RS16800 3666753..3668057 + 1305 WP_137333479.1 MFS transporter -
FAZ95_RS16805 3668199..3668630 + 432 WP_137333480.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-90)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13433.36 Da        Isoelectric Point: 9.5309

>T124883 WP_137333475.1 NZ_CP040077:3663473-3663817 [Burkholderia sp. DHOD12]
MQATFIELPPFSRERENYLADDEYAVLQKELLANPEAGDLIKGTGGLRKLRFADKRRQKGKRGGLRVIYYYWVSGYQFWL
FTLYDKDEMADLTSDERKAFAKLLEREVTIRSKQ

Download         Length: 345 bp

>T124883 NZ_CP040077:3663473-3663817 [Burkholderia sp. DHOD12]
ATGCAAGCGACCTTCATCGAACTGCCGCCATTTTCCCGTGAACGCGAAAACTACCTCGCGGATGACGAGTACGCCGTCCT
TCAGAAAGAGCTGCTGGCCAATCCCGAGGCTGGTGACTTGATCAAGGGAACCGGCGGTCTGCGGAAGTTGAGGTTCGCTG
ACAAACGCCGCCAGAAAGGCAAACGCGGTGGCCTACGAGTGATCTATTACTACTGGGTCAGCGGTTATCAATTCTGGTTG
TTCACACTGTACGACAAGGATGAGATGGCAGACCTAACCAGTGACGAGCGGAAAGCCTTCGCGAAGCTACTGGAAAGAGA
GGTCACGATACGGAGCAAGCAATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11646.50 Da        Isoelectric Point: 10.0926

>AT124883 WP_137333476.1 NZ_CP040077:3663814-3664128 [Burkholderia sp. DHOD12]
MKKRNLFAELTEGLDALAAEREEKITLRKIKAEVPDALDISPAEIKAVREASHASQAVMARSLRINVRTYQNWEQGKAKP
NAQAATLIRLVAKHPETLQMLETL

Download         Length: 315 bp

>AT124883 NZ_CP040077:3663814-3664128 [Burkholderia sp. DHOD12]
ATGAAGAAGCGAAACCTGTTTGCTGAATTGACCGAGGGTCTCGACGCCCTTGCTGCCGAGCGCGAAGAGAAAATCACGCT
GCGCAAGATCAAGGCCGAAGTGCCCGATGCGCTCGACATCTCGCCGGCCGAAATCAAGGCCGTACGCGAAGCCTCTCACG
CGTCTCAAGCCGTCATGGCCCGAAGCCTGCGCATCAACGTGCGCACGTATCAGAATTGGGAACAAGGCAAGGCCAAGCCC
AATGCGCAGGCTGCCACGCTGATCCGACTGGTCGCCAAGCACCCCGAAACGCTTCAGATGCTGGAAACGCTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References