Detailed information of TA system TA124876

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 30448..30687
• Replicon: plasmid p_unnamed3
• Accession: NZ_CP040070
• Organism: Escherichia coli strain A1_181

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: A0A762TWR7
• Locus tag: FDP43_RS25470
• Protein ID: WP_023144756.1
• Coordinates: 30448..30582 (-)
• Length: 45 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	30627..30687 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDP43_RS25430	25795..26210	-	416	Protein_34	IS1 family transposase	-
FDP43_RS25435	26459..26860	-	402	WP_001398199.1	type II toxin-antitoxin system toxin endoribonuclease PemK	-
FDP43_RS25440	26793..27050	-	258	WP_000557619.1	type II toxin-antitoxin system antitoxin PemI	-
FDP43_RS25445	27143..27796	-	654	WP_000616807.1	CPBP family intramembrane metalloprotease	-
FDP43_RS25455	28736..29593	-	858	WP_000130640.1	incFII family plasmid replication initiator RepA	-
FDP43_RS25460	29586..29660	-	75	WP_031943482.1	RepA leader peptide Tap	-
FDP43_RS26385	29657..29791	-	135	Protein_40	protein CopA/IncA	-
FDP43_RS25465	29897..30151	-	255	WP_000083850.1	replication regulatory protein RepA	-
FDP43_RS25470	30448..30582	-	135	WP_023144756.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	30627..30687	+	61	NuclAT_0	-	Antitoxin
-	30627..30687	+	61	NuclAT_0	-	Antitoxin
-	30627..30687	+	61	NuclAT_0	-	Antitoxin
-	30627..30687	+	61	NuclAT_0	-	Antitoxin
FDP43_RS25475	30654..30940	-	287	Protein_43	DUF2726 domain-containing protein	-
FDP43_RS25485	31453..31665	-	213	WP_013023861.1	hypothetical protein	-
FDP43_RS25490	31796..32356	-	561	WP_000139341.1	fertility inhibition protein FinO	-
FDP43_RS25495	32411..33157	-	747	WP_000205718.1	conjugal transfer pilus acetylase TraX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	erm(B) / mph(A) / sul1 / qacE / aadA5	-	1..82718	82718

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (4-44)

Sequences

Toxin

Protein

• Length: 45 a.a.
• Molecular weight: 4896.90 Da
• Isoelectric Point: 7.7209

>T124876 WP_023144756.1 NZ_CP040070:c30582-30448 [Escherichia coli]
MTKYTLIGLLAVCATVLCFSLIFREQLCELNIHRGNTVVQVTLA

Nucleotide

• Length: 135 bp

>T124876 NZ_CP040070:c30582-30448 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT124876 NZ_CP040070:30627-30687 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Structures

Toxin

• AlphaFold DB: A0A762TWR7

Antitoxin