Detailed information of TA system TA124868

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3932163..3932421
• Replicon: chromosome
• Accession: NZ_CP040067
• Organism: Escherichia coli strain A1_181

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: FDP43_RS19175
• Protein ID: WP_000809168.1
• Coordinates: 3932269..3932421 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3932163..3932220 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDP43_RS26075	3927217..3927993	+	777	WP_166666977.1	fimbria/pilus outer membrane usher protein	-
FDP43_RS26355	3928168..3928542	+	375	WP_021521651.1	hypothetical protein	-
FDP43_RS19160	3928555..3929513	+	959	Protein_3710	fimbrial family protein	-
FDP43_RS19165	3929552..3930451	-	900	WP_001300855.1	transcriptional activator NhaR	-
FDP43_RS19170	3930517..3931683	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	3932163..3932220	-	58	-	-	Antitoxin
FDP43_RS19175	3932269..3932421	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
FDP43_RS19180	3932525..3933655	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
FDP43_RS19185	3933744..3935660	-	1917	WP_000516131.1	molecular chaperone DnaK	-
FDP43_RS19190	3936037..3936441	+	405	WP_000843559.1	DUF2541 family protein	-
FDP43_RS19195	3936467..3937180	+	714	WP_001102383.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T124868 WP_000809168.1 NZ_CP040067:3932269-3932421 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T124868 NZ_CP040067:3932269-3932421 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT124868 NZ_CP040067:c3932220-3932163 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin