Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1913183..1913792 Replicon chromosome
Accession NZ_CP040021
Organism Salinivibrio kushneri strain AL184

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FCN78_RS08975 Protein ID WP_077521192.1
Coordinates 1913183..1913464 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag FCN78_RS08980 Protein ID WP_077659396.1
Coordinates 1913478..1913792 (+) Length 105 a.a.

Genomic Context

FCN78_RS08945FCN78_RS08950FCN78_RS08955FCN78_RS08960FCN78_RS08965FCN78_RS08970FCN78_RS08975FCN78_RS08980FCN78_RS08985FCN78_RS08990FCN78_RS08995FCN78_RS09000FCN78_RS09005
Location: 1908186..1909238 (1053 bp)
Type: Others
Protein ID: WP_106407191.1
Location: 1909250..1910317 (1068 bp)
Type: Others
Protein ID: WP_077659399.1
Location: 1910317..1910916 (600 bp)
Type: Others
Protein ID: WP_077659398.1
Location: 1910923..1911660 (738 bp)
Type: Others
Protein ID: WP_069361210.1
Location: 1911642..1912415 (774 bp)
Type: Others
Protein ID: WP_069361209.1
Location: 1912412..1913035 (624 bp)
Type: Others
Protein ID: WP_077659397.1
Location: 1913183..1913464 (282 bp)
Type: Toxin
Protein ID: WP_077521192.1
Location: 1913478..1913792 (315 bp)
Type: Antitoxin
Protein ID: WP_077659396.1
Location: 1913881..1914876 (996 bp)
Type: Others
Protein ID: WP_077521186.1
Location: 1914889..1916034 (1146 bp)
Type: Others
Protein ID: WP_077659476.1
Location: 1916038..1916742 (705 bp)
Type: Others
Protein ID: WP_077649303.1
Location: 1916739..1917815 (1077 bp)
Type: Others
Protein ID: WP_077659395.1
Location: 1917806..1918384 (579 bp)
Type: Others
Protein ID: WP_077659394.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FCN78_RS089451908186..1909238+1053WP_106407191.1histidinol-phosphate transaminase-
FCN78_RS089501909250..1910317+1068WP_077659399.1bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB-
FCN78_RS089551910317..1910916+600WP_077659398.1imidazole glycerol phosphate synthase subunit HisH-
FCN78_RS089601910923..1911660+738WP_069361210.11-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase-
FCN78_RS089651911642..1912415+774WP_069361209.1imidazole glycerol phosphate synthase subunit HisF-
FCN78_RS089701912412..1913035+624WP_077659397.1bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE-
FCN78_RS089751913183..1913464+282WP_077521192.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FCN78_RS089801913478..1913792+315WP_077659396.1HigA family addiction module antidote proteinAntitoxin
FCN78_RS089851913881..1914876+996WP_077521186.1UDP-N-acetylglucosamine 4,6-dehydratase (inverting)-
FCN78_RS089901914889..1916034+1146WP_077659476.1UDP-4-amino-4, 6-dideoxy-N-acetyl-beta-L-altrosamine transaminase-
FCN78_RS089951916038..1916742+705WP_077649303.1pseudaminic acid cytidylyltransferase-
FCN78_RS090001916739..1917815+1077WP_077659395.1UDP-2,4-diacetamido-2,4, 6-trideoxy-beta-L-altropyranose hydrolase-
FCN78_RS090051917806..1918384+579WP_077659394.1UDP-4-amino-4, 6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(11-89)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10725.18 Da        Isoelectric Point: 9.0192

>T124757 WP_077521192.1 NZ_CP040021:1913183-1913464 [Salinivibrio kushneri]
MIKSFADKRTQALYSKGTSKRFPTELTVRAARKLEYIDLATQLDDLKVPPGNRLHALSGNRQGQYAIAINKQWRICFRFE
DGDAYDVEVCDYH

Download         Length: 282 bp

>T124757 NZ_CP040021:1913183-1913464 [Salinivibrio kushneri]
ATGATCAAATCATTCGCAGATAAACGAACGCAGGCACTATACTCAAAGGGAACGTCAAAGAGGTTCCCTACCGAGCTGAC
GGTACGTGCGGCAAGAAAGTTGGAGTATATCGATCTCGCCACACAGCTCGATGATCTCAAGGTACCGCCCGGTAATCGCC
TTCACGCTTTGTCAGGAAACAGACAAGGGCAATATGCAATAGCGATAAACAAACAGTGGCGCATTTGCTTTCGCTTTGAA
GACGGTGACGCGTATGACGTCGAGGTTTGCGACTACCACTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11605.33 Da        Isoelectric Point: 5.6864

>AT124757 WP_077659396.1 NZ_CP040021:1913478-1913792 [Salinivibrio kushneri]
MTIFNTTGMQRQPTHPGAMLREDFLPDYGLSVEQLADALGVSRQSMIAVLDERKAVSPELALRLARLFGNSPEFWLNAQR
AVDLWEASQSIKHEVAKIKPLDVA

Download         Length: 315 bp

>AT124757 NZ_CP040021:1913478-1913792 [Salinivibrio kushneri]
ATGACGATTTTCAATACAACTGGCATGCAACGCCAACCGACGCATCCTGGAGCCATGTTGCGCGAAGACTTTCTGCCCGA
TTACGGCTTGAGTGTAGAACAATTGGCTGATGCTTTGGGCGTCTCTCGTCAATCGATGATTGCCGTATTGGATGAGCGTA
AAGCCGTGAGCCCGGAGCTGGCGCTTCGTCTCGCTCGTCTGTTTGGTAACTCGCCTGAGTTTTGGCTCAATGCGCAAAGG
GCCGTTGATCTTTGGGAGGCGTCGCAATCAATTAAACACGAGGTAGCAAAAATAAAACCGCTTGATGTCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References