Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 250684..251345 Replicon chromosome
Accession NZ_CP040020
Organism Brevibacterium sp. CS2

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag FDF13_RS01130 Protein ID WP_137318085.1
Coordinates 250684..251034 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag FDF13_RS01135 Protein ID WP_137318086.1
Coordinates 251040..251345 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDF13_RS01115 245899..248016 - 2118 WP_137318082.1 acetyl-CoA carboxylase biotin carboxylase subunit -
FDF13_RS01120 248018..249631 - 1614 WP_137318083.1 methylcrotonoyl-CoA carboxylase -
FDF13_RS01125 249686..250399 + 714 WP_137318084.1 TetR/AcrR family transcriptional regulator -
FDF13_RS14570 250432..250608 - 177 WP_175406794.1 hypothetical protein -
FDF13_RS01130 250684..251034 + 351 WP_137318085.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FDF13_RS01135 251040..251345 + 306 WP_137318086.1 helix-turn-helix domain-containing protein Antitoxin
FDF13_RS01140 251362..251952 - 591 WP_137318087.1 histone deacetylase -
FDF13_RS01145 252184..253659 - 1476 WP_137318088.1 RNB domain-containing ribonuclease -
FDF13_RS01150 253682..254320 - 639 WP_137318089.1 NUDIX hydrolase -
FDF13_RS01155 254362..255237 - 876 WP_137318090.1 universal stress protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 231512..251345 19833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-88)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13387.24 Da        Isoelectric Point: 6.6089

>T124753 WP_137318085.1 NZ_CP040020:250684-251034 [Brevibacterium sp. CS2]
MWVVDIELISEWLASLDDDSREHVVAAVELLEEHGPHLGRPLVDTVVASRHRNMKELRPGSSGRSELRILFAFDPRRHAI
LLIAGDKAGRWKSWYRRHIPSADDLFDEHLRTMEGK

Download         Length: 351 bp

>T124753 NZ_CP040020:250684-251034 [Brevibacterium sp. CS2]
ATGTGGGTCGTCGACATCGAACTGATCTCAGAATGGCTCGCGTCACTCGATGACGACTCCCGCGAACACGTCGTCGCAGC
TGTCGAACTTCTCGAGGAACACGGTCCGCACCTGGGGCGTCCACTTGTGGACACCGTGGTCGCATCTCGCCACCGGAACA
TGAAGGAACTGCGACCGGGCTCGAGCGGCCGGTCGGAGCTGCGAATCCTCTTCGCCTTCGACCCGCGTCGCCACGCGATC
CTCTTGATCGCTGGAGACAAGGCGGGACGCTGGAAGAGCTGGTATCGGAGACACATCCCGAGTGCCGACGACCTCTTCGA
TGAACATCTGCGCACCATGGAAGGAAAGTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11451.07 Da        Isoelectric Point: 7.2060

>AT124753 WP_137318086.1 NZ_CP040020:251040-251345 [Brevibacterium sp. CS2]
MAMKINEFLAEHPIDRERVDAHKERMLSEVRAYRLRELRADAGLTQVEVAQRIGVSQRQVSKIERGDLESTKIGTIRRYL
EAVGGDLAIEFVTGDSRVQVA

Download         Length: 306 bp

>AT124753 NZ_CP040020:251040-251345 [Brevibacterium sp. CS2]
ATGGCAATGAAGATCAACGAGTTCCTTGCCGAGCACCCGATCGATCGCGAACGCGTCGATGCGCACAAGGAACGGATGCT
CAGCGAAGTGCGCGCCTACCGACTCCGTGAACTGCGGGCCGATGCTGGTCTGACTCAAGTGGAGGTGGCACAACGGATCG
GCGTCTCACAGCGCCAGGTCTCGAAGATCGAGCGCGGCGACCTCGAGAGTACGAAGATCGGCACGATTCGCCGCTACCTG
GAAGCGGTGGGCGGCGACCTCGCCATCGAATTCGTCACCGGAGACTCACGGGTTCAGGTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References