Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2277079..2277737 Replicon chromosome
Accession NZ_CP040018
Organism Arthrobacter sp. 24S4-2

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag FCN77_RS10365 Protein ID WP_137322210.1
Coordinates 2277079..2277432 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag FCN77_RS10370 Protein ID WP_137322211.1
Coordinates 2277432..2277737 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCN77_RS25910 2274455..2274958 - 504 WP_175417210.1 amidohydrolase family protein -
FCN77_RS10355 2275438..2275671 - 234 Protein_2025 transposase -
FCN77_RS25915 2275668..2275913 - 246 WP_175417084.1 hypothetical protein -
FCN77_RS10360 2276045..2276881 - 837 Protein_2027 IS256 family transposase -
FCN77_RS10365 2277079..2277432 + 354 WP_137322210.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FCN77_RS10370 2277432..2277737 + 306 WP_137322211.1 XRE family transcriptional regulator Antitoxin
FCN77_RS10375 2279787..2280818 - 1032 Protein_2030 DUF4192 domain-containing protein -
FCN77_RS10380 2281927..2282501 - 575 Protein_2031 aldo/keto reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2268106..2283588 15482


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13254.25 Da        Isoelectric Point: 5.7572

>T124752 WP_137322210.1 NZ_CP040018:2277079-2277432 [Arthrobacter sp. 24S4-2]
MWNVDVGLMEPWLLGLDQDSYEQVVAALELLAERGPQLGRPLVDTVVRSRHKNMKELRPGSSGRSELRILFAFDPERRAI
LLVAGDKAGSWTKWYKANIPVADDLFDEHLRILKGEA

Download         Length: 354 bp

>T124752 NZ_CP040018:2277079-2277432 [Arthrobacter sp. 24S4-2]
ATGTGGAATGTTGACGTGGGACTCATGGAGCCGTGGCTATTAGGTCTTGACCAAGACTCGTATGAGCAGGTTGTTGCTGC
ACTGGAGCTTCTCGCCGAGCGCGGACCTCAACTTGGTCGTCCGTTGGTCGACACGGTGGTTCGTTCACGGCATAAGAACA
TGAAGGAACTGCGCCCGGGATCGAGCGGGCGGTCGGAACTGCGAATCCTATTTGCCTTTGATCCGGAGCGGCGGGCGATC
CTGCTTGTCGCGGGGGACAAAGCGGGTAGCTGGACCAAGTGGTACAAGGCGAACATTCCGGTTGCGGATGACCTGTTTGA
CGAGCATCTGAGGATTCTGAAAGGAGAGGCATAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11692.32 Da        Isoelectric Point: 6.7334

>AT124752 WP_137322211.1 NZ_CP040018:2277432-2277737 [Arthrobacter sp. 24S4-2]
MAKSMEELLAERPVDRTAVDTHKKRMLDEVRAYRLRELREASELTQVELAGRLHVSQNRVSRIEHGDIDRAQVDTLRKYV
EALGGRLRVEVELGDERIQIA

Download         Length: 306 bp

>AT124752 NZ_CP040018:2277432-2277737 [Arthrobacter sp. 24S4-2]
ATGGCGAAGTCCATGGAGGAACTGCTGGCTGAGCGTCCGGTTGACCGGACTGCTGTGGATACCCACAAGAAGCGCATGCT
CGATGAAGTCCGGGCCTATCGGCTTCGGGAGCTCCGTGAGGCCTCGGAGCTGACGCAGGTCGAGCTGGCTGGGCGTTTGC
ACGTCAGCCAGAACCGGGTATCCCGCATCGAACATGGTGACATTGATCGCGCCCAGGTCGACACCTTGCGGAAATACGTT
GAGGCGCTCGGCGGCCGACTTCGTGTTGAGGTTGAACTCGGCGACGAACGAATCCAAATCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References