Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2840109..2840616 Replicon chromosome
Accession NZ_CP040007
Organism Arachnia propionica strain F0700

Toxin (Protein)


Gene name yoeB Uniprot ID A0A4V1GCM1
Locus tag FBF34_RS12815 Protein ID WP_014847590.1
Coordinates 2840109..2840363 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A3N4D924
Locus tag FBF34_RS12820 Protein ID WP_014847591.1
Coordinates 2840365..2840616 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FBF34_RS12785 2836349..2836822 - 474 WP_014847587.1 GNAT family N-acetyltransferase -
FBF34_RS12790 2836927..2837712 - 786 WP_051015054.1 MFS transporter -
FBF34_RS12795 2837696..2838328 - 633 Protein_2535 MFS transporter -
FBF34_RS12800 2838382..2839206 + 825 WP_014847588.1 class I SAM-dependent methyltransferase -
FBF34_RS12805 2839214..2839450 - 237 WP_014847589.1 antitoxin -
FBF34_RS12810 2839769..2840050 + 282 WP_123824087.1 hypothetical protein -
FBF34_RS12815 2840109..2840363 - 255 WP_014847590.1 Txe/YoeB family addiction module toxin Toxin
FBF34_RS12820 2840365..2840616 - 252 WP_014847591.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FBF34_RS12825 2840794..2841378 - 585 WP_014847592.1 TetR family transcriptional regulator -
FBF34_RS12830 2841449..2842678 + 1230 WP_014847593.1 MFS transporter -
FBF34_RS12835 2842665..2843618 - 954 WP_014847594.1 NmrA/HSCARG family protein -
FBF34_RS12840 2843740..2844123 + 384 WP_014847595.1 helix-turn-helix transcriptional regulator -
FBF34_RS12845 2844199..2845236 + 1038 WP_051015057.1 DUF2330 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-69)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9826.09 Da        Isoelectric Point: 6.4548

>T124747 WP_014847590.1 NZ_CP040007:c2840363-2840109 [Arachnia propionica]
VRLAWDPSAWEDYTYWQAADSRILKRINALIDTCLRDPFGGIGKPEQLRYGATGAWSRRITEEHRLVYLVDGDDLVILQA
RYHY

Download         Length: 255 bp

>T124747 NZ_CP040007:c2840363-2840109 [Arachnia propionica]
GTGCGCCTGGCGTGGGATCCCTCGGCCTGGGAGGATTACACGTACTGGCAGGCCGCGGATAGCCGGATTCTCAAGCGGAT
CAACGCGCTCATCGACACCTGCCTCCGCGATCCCTTCGGTGGGATCGGGAAACCTGAACAACTCAGGTATGGGGCAACGG
GGGCTTGGTCGCGGCGCATCACGGAGGAGCACCGGCTCGTGTATCTCGTCGACGGCGACGACCTGGTGATCCTCCAGGCC
CGGTACCACTACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9497.50 Da        Isoelectric Point: 4.6794

>AT124747 WP_014847591.1 NZ_CP040007:c2840616-2840365 [Arachnia propionica]
VSISASEARRTLFPLIEQVNDDRTAVEIVSRKGNAVLMSADEYAAWQETAYLFRSPANARRLLDAYERAREGRSEEHDLI
RED

Download         Length: 252 bp

>AT124747 NZ_CP040007:c2840616-2840365 [Arachnia propionica]
GTGTCCATCAGCGCCAGCGAGGCCCGCAGGACGTTGTTCCCGCTCATCGAGCAGGTCAACGACGATCGCACTGCCGTCGA
GATCGTTTCCCGCAAGGGGAACGCCGTTCTCATGTCCGCCGATGAATACGCCGCGTGGCAGGAGACGGCCTACCTGTTCC
GTTCCCCCGCCAATGCCCGAAGGCTGCTCGACGCCTACGAGAGGGCCCGGGAAGGACGGAGCGAGGAACACGATCTCATC
CGGGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V1GCM1

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4D924

References