Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2371094..2371611 Replicon chromosome
Accession NZ_CP039992
Organism Staphylococcus aureus strain Lr3

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag E1E63_RS11995 Protein ID WP_000113262.1
Coordinates 2371094..2371360 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E1E63_RS12000 Protein ID WP_000584499.1
Coordinates 2371360..2371611 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1E63_RS11970 2366518..2367054 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
E1E63_RS11975 2367288..2368112 - 825 WP_000594630.1 formate/nitrite transporter family protein -
E1E63_RS11980 2368328..2368513 - 186 WP_000230293.1 hypothetical protein -
E1E63_RS11985 2368597..2369064 - 468 WP_000153344.1 SRPBCC domain-containing protein -
E1E63_RS11990 2369250..2370800 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E1E63_RS11995 2371094..2371360 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
E1E63_RS12000 2371360..2371611 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E1E63_RS12005 2371776..2371877 - 102 WP_031867537.1 hypothetical protein -
E1E63_RS12010 2371884..2372483 - 600 WP_000162799.1 DsbA family protein -
E1E63_RS12015 2372502..2372864 - 363 WP_000819843.1 DUF4467 domain-containing protein -
E1E63_RS12020 2373119..2374369 + 1251 WP_001012219.1 FemA/FemB family glycyltransferase FmhA -
E1E63_RS12025 2374466..2375197 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
E1E63_RS12030 2375194..2375913 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T124731 WP_000113262.1 NZ_CP039992:c2371360-2371094 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T124731 NZ_CP039992:c2371360-2371094 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT124731 WP_000584499.1 NZ_CP039992:c2371611-2371360 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT124731 NZ_CP039992:c2371611-2371360 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References