Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2121922..2122184 Replicon chromosome
Accession NZ_CP039992
Organism Staphylococcus aureus strain Lr3

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag E1E63_RS10665 Protein ID WP_001802298.1
Coordinates 2122080..2122184 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2121922..2122085 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1E63_RS10645 2118174..2118839 - 666 WP_001024095.1 SDR family oxidoreductase -
E1E63_RS10650 2118991..2119311 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
E1E63_RS10655 2119313..2120290 + 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
E1E63_RS10660 2120556..2121647 + 1092 WP_000495669.1 hypothetical protein -
- 2121922..2122085 + 164 - - Antitoxin
E1E63_RS10665 2122080..2122184 - 105 WP_001802298.1 hypothetical protein Toxin
E1E63_RS10675 2122864..2123022 + 159 WP_001792784.1 hypothetical protein -
E1E63_RS10685 2123680..2124537 - 858 WP_000370925.1 Cof-type HAD-IIB family hydrolase -
E1E63_RS10690 2124605..2125387 - 783 WP_000908182.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T124729 WP_001802298.1 NZ_CP039992:c2122184-2122080 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T124729 NZ_CP039992:c2122184-2122080 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 164 bp

>AT124729 NZ_CP039992:2121922-2122085 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References