124471

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2184131..2184999 Replicon chromosome
Accession NZ_CP039851
Organism Mycobacterium tuberculosis variant bovis strain Danish delta-sapM

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag FCU27_RS10590 Protein ID WP_010886136.1
Coordinates 2184131..2184508 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag FCU27_RS10595 Protein ID WP_003409886.1
Coordinates 2184550..2184999 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCU27_RS10540 2179920..2180372 - 453 WP_010950636.1 lipoprotein -
FCU27_RS10545 2180436..2180837 + 402 WP_003409869.1 hypothetical protein -
FCU27_RS10550 2180830..2181012 - 183 WP_003409870.1 hypothetical protein -
FCU27_RS10555 2181126..2181476 - 351 WP_003409871.1 hypothetical protein -
FCU27_RS10560 2181487..2182389 - 903 WP_003409874.1 hypothetical protein -
FCU27_RS10565 2182410..2182601 - 192 WP_003409876.1 hypothetical protein -
FCU27_RS10570 2182602..2182898 - 297 WP_003409877.1 hypothetical protein -
FCU27_RS10575 2183138..2183353 + 216 WP_003409878.1 antitoxin -
FCU27_RS10580 2183350..2183661 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FCU27_RS21325 2183635..2184156 - 522 WP_010950637.1 hypothetical protein -
FCU27_RS10590 2184131..2184508 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
FCU27_RS10595 2184550..2184999 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
FCU27_RS10600 2184996..2185541 + 546 WP_003409891.1 SecB-like chaperone -
FCU27_RS10605 2185430..2186044 - 615 WP_003901296.1 hypothetical protein -
FCU27_RS10610 2186093..2186389 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
FCU27_RS10615 2186386..2186637 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
FCU27_RS10620 2186624..2187118 + 495 WP_003899099.1 hypothetical protein -
FCU27_RS10625 2187278..2187685 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FCU27_RS10630 2187689..2187961 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FCU27_RS10635 2187994..2189214 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(27-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-91)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T124471 WP_010886136.1 NZ_CP039851:2184131-2184508 [Mycobacterium tuberculosis variant bovis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

>T124471 NZ_CP039851:2184131-2184508 [Mycobacterium tuberculosis variant bovis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT124471 WP_003409886.1 NZ_CP039851:2184550-2184999 [Mycobacterium tuberculosis variant bovis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp

>AT124471 NZ_CP039851:2184550-2184999 [Mycobacterium tuberculosis variant bovis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU

Antitoxin

Source ID Structure
AlphaFold DB G0TLM0

References