Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2225448..2226367 Replicon chromosome
Accession NZ_CP039850
Organism Mycobacterium tuberculosis variant bovis strain Danish 1331

Toxin (Protein)


Gene name HigB2 Uniprot ID L7N4R2
Locus tag FCU26_RS10860 Protein ID WP_003900449.1
Coordinates 2225762..2226367 (-) Length 202 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID L7N5K9
Locus tag FCU26_RS10855 Protein ID WP_003410124.1
Coordinates 2225448..2225753 (-) Length 102 a.a.

Genomic Context

FCU26_RS10830FCU26_RS10835FCU26_RS10840FCU26_RS10845FCU26_RS10820FCU26_RS10850FCU26_RS10855FCU26_RS10860FCU26_RS10865FCU26_RS10870FCU26_RS10875FCU26_RS10880
Location: 2222069..2222644 (576 bp)
Type: Others
Protein ID: WP_003410100.1
Location: 2222641..2223681 (1041 bp)
Type: Others
Protein ID: WP_003410103.1
Location: 2223923..2224642 (720 bp)
Type: Others
Protein ID: WP_010950643.1
Location: 2224632..2225048 (417 bp)
Type: Others
Protein ID: WP_003410114.1
Location: 2220459..2221715 (1257 bp)
Type: Others
Protein ID: WP_003410095.1
Location: 2225064..2225363 (300 bp)
Type: Others
Protein ID: WP_003410120.1
Location: 2225448..2225753 (306 bp)
Type: Antitoxin
Protein ID: WP_003410124.1
Location: 2225762..2226367 (606 bp)
Type: Toxin
Protein ID: WP_003900449.1
Location: 2226392..2226751 (360 bp)
Type: Others
Protein ID: WP_003410131.1
Location: 2226911..2227588 (678 bp)
Type: Others
Protein ID: WP_003900450.1
Location: 2227540..2227776 (237 bp)
Type: Others
Protein ID: WP_003410133.1
Location: 2227983..2228879 (897 bp)
Type: Others
Protein ID: WP_011799238.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FCU26_RS108202220459..2221715-1257WP_003410095.1HNH endonuclease-
FCU26_RS108302222069..2222644+576WP_003410100.1hypothetical protein-
FCU26_RS108352222641..2223681+1041WP_003410103.1ImmA/IrrE family metallo-endopeptidase-
FCU26_RS108402223923..2224642+720WP_010950643.1DUF433 domain-containing protein-
FCU26_RS108452224632..2225048+417WP_003410114.1hypothetical protein-
FCU26_RS108502225064..2225363-300WP_003410120.1hypothetical protein-
FCU26_RS108552225448..2225753-306WP_003410124.1XRE family transcriptional regulatorAntitoxin
FCU26_RS108602225762..2226367-606WP_003900449.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FCU26_RS108652226392..2226751-360WP_003410131.1hypothetical protein-
FCU26_RS108702226911..2227588-678WP_003900450.1hypothetical protein-
FCU26_RS108752227540..2227776-237WP_003410133.1hypothetical protein-
FCU26_RS108802227983..2228879-897WP_011799238.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(86-181)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 202 a.a.        Molecular weight: 22744.96 Da        Isoelectric Point: 7.3073

>T124416 WP_003900449.1 NZ_CP039850:c2226367-2225762 [Mycobacterium tuberculosis variant bovis]
VNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG

Download         Length: 606 bp

>T124416 NZ_CP039850:c2226367-2225762 [Mycobacterium tuberculosis variant bovis]
GTGAACGTTCCATGGGAGAACGCGCACGGCGGCGCACTGTACTGCCTCATACGTGGGGATGAATTCTCGGCCTGGCACAG
GCTACTGTTTCAACGGCCCGGGTGCGCAGAGTCCGTCCTCGCCTGCCGGCATTTCCTCGACGGTAGCCCCGTCGCCCGCT
GCTCTTACCCGGAGGAATATCACCCTTGTGTGATATCGCGTATCGCGCTACTCTGCGACTCTGTGGGGTGGACGGCGGAT
GTGGAGCGCATCTCCGCCTGGCTCAACGGCTTGGACCGAGAGACCTACGAATTGGTGTTCGCAGCTATCGAGGTTCTCGA
GGAAGAGGGCCCCGCACTTGGCTGTCCTCTGGTGGACACGGTGCGTGGGTCGCGCCACAAGAACATGAAGGAGCTGCGTC
CAGGATCACAAGGGCGGTCCGAGGTCCGCATTCTGTTCGCCTTCGACCCGGCGCGGCAGGCGATCATGCTGGCCGCCGGT
AACAAGGCCGGGCGGTGGACCCAGTGGTACGACGAGAAGATCAAAGCGGCCGATGAGATGTTTGCCGAACATCTCGCACA
GTTCGAGGACACGAAGCCAAAGAGGCGCAAGCGCAAGAAAGGGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11291.91 Da        Isoelectric Point: 10.7482

>AT124416 WP_003410124.1 NZ_CP039850:c2225753-2225448 [Mycobacterium tuberculosis variant bovis]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA

Download         Length: 306 bp

>AT124416 NZ_CP039850:c2225753-2225448 [Mycobacterium tuberculosis variant bovis]
ATGGCGATGACACTACGGGACATGGACGCCGTACGTCCCGTTAACCGGGAGGCGGTGGACCGGCACAAGGCACGAATGCG
CGATGAAGTGCGGGCATTCCGGCTCCGGGAGCTGCGCGCGGCTCAGTCACTCACCCAGGTCCAGGTGGCTGCGCTGGCGC
ACATCCGGCAGAGCCGGGTATCCAGCATCGAGAACGGCGACATCGGCTCCGCACAGGTCAACACACTGCGCAAATACGTG
TCCGCTCTTGGCGGAGAACTGGATATCACCGTCCGCCTGGGAGATGAGACATTCACCCTGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U4BV20

Antitoxin

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Source
ID
Structure
PDB7EWC
PDB7EWD
PDB7EWE
AlphaFold DBA0A7U4BV30

References