Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4818736..4819148 Replicon chromosome
Accession NZ_CP039834
Organism Escherichia coli O157:H7 strain MB41-1

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag FCV42_RS24200 Protein ID WP_000132630.1
Coordinates 4818807..4819148 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4818736..4818812 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCV42_RS24190 4815363..4816832 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
FCV42_RS24195 4816832..4818586 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4818736..4818812 - 77 NuclAT_15 - Antitoxin
- 4818736..4818812 - 77 NuclAT_15 - Antitoxin
- 4818736..4818812 - 77 NuclAT_15 - Antitoxin
- 4818736..4818812 - 77 NuclAT_15 - Antitoxin
- 4818736..4818812 - 77 NuclAT_16 - Antitoxin
- 4818736..4818812 - 77 NuclAT_16 - Antitoxin
- 4818736..4818812 - 77 NuclAT_16 - Antitoxin
- 4818736..4818812 - 77 NuclAT_16 - Antitoxin
FCV42_RS24200 4818807..4819148 + 342 WP_000132630.1 endoribonuclease SymE Toxin
FCV42_RS24205 4819195..4820358 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
FCV42_RS24210 4820406..4821287 - 882 WP_001304007.1 DUF262 domain-containing protein -
FCV42_RS24215 4821384..4821548 - 165 WP_000394274.1 DUF1127 domain-containing protein -
FCV42_RS24220 4821725..4823137 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
FCV42_RS24225 4823380..4823580 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4810935..4832162 21227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T124330 WP_000132630.1 NZ_CP039834:4818807-4819148 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T124330 NZ_CP039834:4818807-4819148 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT124330 NZ_CP039834:c4818812-4818736 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References