Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1370147..1370799 Replicon chromosome
Accession NZ_CP039832
Organism Aeromonas caviae strain WCW1-2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FCM34_RS06520 Protein ID WP_143237256.1
Coordinates 1370449..1370799 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FCM34_RS06515 Protein ID WP_042046566.1
Coordinates 1370147..1370449 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCM34_RS06495 1366545..1367216 - 672 WP_080989999.1 hypothetical protein -
FCM34_RS06500 1367685..1368032 + 348 WP_052815692.1 helix-turn-helix domain-containing protein -
FCM34_RS06505 1368034..1368972 - 939 WP_052815691.1 hypothetical protein -
FCM34_RS06510 1368969..1369970 - 1002 WP_052815690.1 YqaJ viral recombinase family protein -
FCM34_RS06515 1370147..1370449 - 303 WP_042046566.1 XRE family transcriptional regulator Antitoxin
FCM34_RS06520 1370449..1370799 - 351 WP_143237256.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FCM34_RS06525 1370847..1371797 - 951 WP_143237257.1 DUF932 domain-containing protein -
FCM34_RS06530 1372257..1374323 - 2067 WP_143237258.1 hypothetical protein -
FCM34_RS06535 1374423..1374635 + 213 WP_052815957.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1361447..1440823 79376


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12996.88 Da        Isoelectric Point: 5.7411

>T124303 WP_143237256.1 NZ_CP039832:c1370799-1370449 [Aeromonas caviae]
MWTVKTTELFDAWFDVQDEATQEKVLAGLLALAQDGPSVGRPLVDTIKGSRFTNMKELRVQHQGEPLRAFFAFDPLRQAI
VLCAGNKGGNEKRFYKEMLPLAEAQYASHLAELEGK

Download         Length: 351 bp

>T124303 NZ_CP039832:c1370799-1370449 [Aeromonas caviae]
ATGTGGACAGTAAAAACAACCGAGCTGTTTGATGCTTGGTTTGATGTACAAGATGAAGCGACGCAGGAGAAAGTCTTGGC
CGGGCTACTCGCCTTAGCGCAGGACGGCCCATCGGTAGGACGTCCCCTGGTCGATACCATCAAGGGCTCGCGTTTTACAA
ACATGAAAGAGCTGAGGGTACAGCATCAGGGGGAGCCGCTACGTGCATTCTTCGCCTTTGACCCGTTGCGACAAGCCATT
GTGCTGTGTGCTGGCAACAAGGGCGGGAACGAGAAGCGGTTTTACAAAGAGATGCTGCCGTTGGCTGAGGCACAGTACGC
CAGTCATCTGGCTGAGTTGGAGGGAAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11179.90 Da        Isoelectric Point: 5.2187

>AT124303 WP_042046566.1 NZ_CP039832:c1370449-1370147 [Aeromonas caviae]
MGRTLDDLLASRSEESRQRIQEMATELLLEVRIQALREELEVSQVELAKALGVSQPAVVAMEQRGSDIKLSTMKRYVEAM
GGKLRVDVELPTGRHIGFNV

Download         Length: 303 bp

>AT124303 NZ_CP039832:c1370449-1370147 [Aeromonas caviae]
ATGGGAAGAACACTTGACGATTTGCTGGCCTCCCGTTCAGAAGAGAGTCGGCAACGCATCCAGGAAATGGCTACCGAGCT
GTTGCTGGAGGTACGTATACAGGCGCTACGCGAAGAGCTGGAAGTGTCACAGGTCGAGTTGGCTAAAGCACTCGGTGTCA
GCCAACCTGCCGTCGTGGCGATGGAGCAGCGTGGCAGTGATATCAAGCTCTCCACCATGAAACGCTATGTCGAAGCCATG
GGCGGCAAGCTGCGTGTGGATGTTGAACTACCAACCGGACGACACATCGGGTTCAACGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References