124220

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1735683..1736247 Replicon chromosome
Accession NZ_CP039707
Organism Lacticaseibacillus paracasei strain Lp02

Toxin (Protein)


Gene name yafQ Uniprot ID A0A510WIJ9
Locus tag FBD73_RS08435 Protein ID WP_016363448.1
Coordinates 1735945..1736247 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID K6SLT0
Locus tag FBD73_RS08430 Protein ID WP_003570051.1
Coordinates 1735683..1735952 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FBD73_RS08400 1730688..1731575 - 888 WP_003570041.1 ABC transporter ATP-binding protein -
FBD73_RS08405 1731772..1732998 - 1227 WP_003570043.1 hypothetical protein -
FBD73_RS08410 1733196..1733600 + 405 WP_003570045.1 MerR family transcriptional regulator -
FBD73_RS08415 1733593..1733919 + 327 WP_003584272.1 YrdB family protein -
FBD73_RS08420 1733982..1734611 + 630 WP_003570047.1 DUF2399 domain-containing protein -
FBD73_RS08425 1734656..1735309 + 654 WP_003570049.1 GNAT family N-acetyltransferase -
FBD73_RS08430 1735683..1735952 + 270 WP_003570051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FBD73_RS08435 1735945..1736247 + 303 WP_016363448.1 type II toxin-antitoxin system YafQ family toxin Toxin
FBD73_RS08440 1736586..1736729 + 144 WP_162259784.1 hypothetical protein -
FBD73_RS08445 1736847..1737539 + 693 WP_003570055.1 hypothetical protein -
FBD73_RS08450 1737775..1739952 + 2178 WP_003570057.1 RNA-binding transcriptional accessory protein -
FBD73_RS08455 1740377..1740934 - 558 WP_003584278.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-97)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11510.33 Da        Isoelectric Point: 9.8881

>T124220 WP_016363448.1 NZ_CP039707:1735945-1736247 [Lacticaseibacillus paracasei]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELYVDGPRGDWLLIYKIE
QQDLILTLVRTGSHHNLLVK

Download         Length: 303 bp

>T124220 NZ_CP039707:1735945-1736247 [Lacticaseibacillus paracasei]
ATGTATAGTCTGGTTCCGACGCCTACATTTAAGCGCGATCTAAAACGACTCTCCAAGAAGCATTGGCCGATGGACGAACT
AAAGACGGCTGTTAATCTCCTAGCCGCTGGTACAAATGCTGAACTATTAAGCAAAAAGTATGCAGATCATGCCTTGTCCT
CAAGCAGCGAGTGGAAAGGATATCGTGAACTATATGTTGACGGCCCTCGTGGCGACTGGTTGCTAATCTATAAAATTGAG
CAGCAAGATCTTATTTTAACCCTAGTTAGAACCGGATCTCATCATAACCTTCTGGTTAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9982.68 Da        Isoelectric Point: 7.2026

>AT124220 WP_003570051.1 NZ_CP039707:1735683-1735952 [Lacticaseibacillus paracasei]
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp

>AT124220 NZ_CP039707:1735683-1735952 [Lacticaseibacillus paracasei]
ATGGCAGCCACAAAGAAGGAAACTCGCTTGAATATTCGTGTTGATCCTGAATTAAAAAGTGCTGCTCAAATCGTAGCAAA
TGATATGGGCATCGACTTGACCGCAGCTGTTACGATGTTCATGACGAAAATGGTGAAAGATCACGCCCTCCCGTTTACCC
CAACAAGTCTACCAGTTGAAACCTTACAGGCGCTGAAAGAAGCAAAGCACCCAGAGCTGCTCAAAAAATACAGCACGCCT
GATGACATGTGGAGAGACTTGAATGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510WIJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2BRK6

References