Detailed information of TA system TA124198

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2175184..2175883
• Replicon: chromosome
• Accession: NZ_CP039691
• Organism: Agrobacterium larrymoorei strain CFBP5473

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A4D7DRI6
• Locus tag: CFBP5473_RS10480
• Protein ID: WP_027675444.1
• Coordinates: 2175184..2175480 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: A0A4D7DPV9
• Locus tag: CFBP5473_RS10485
• Protein ID: WP_027675445.1
• Coordinates: 2175482..2175883 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFBP5473_RS10450	2170460..2170789	+	330	WP_037170972.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CFBP5473_RS10455	2170786..2171067	+	282	WP_027675439.1	helix-turn-helix domain-containing protein	-
CFBP5473_RS10460	2171167..2172003	-	837	WP_027675440.1	undecaprenyl-diphosphate phosphatase	-
CFBP5473_RS10465	2172132..2173529	-	1398	WP_027675441.1	coniferyl aldehyde dehydrogenase	-
CFBP5473_RS10470	2173526..2173924	-	399	WP_027675442.1	helix-turn-helix transcriptional regulator	-
CFBP5473_RS10475	2174062..2175078	+	1017	WP_027675443.1	zinc-binding alcohol dehydrogenase family protein	-
CFBP5473_RS10480	2175184..2175480	+	297	WP_027675444.1	type II toxin-antitoxin system MqsR family toxin	Toxin
CFBP5473_RS10485	2175482..2175883	+	402	WP_027675445.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
CFBP5473_RS10490	2175981..2176727	-	747	WP_027675446.1	pentapeptide repeat-containing protein	-
CFBP5473_RS10495	2176883..2177386	-	504	WP_051441274.1	GNAT family N-acetyltransferase	-
CFBP5473_RS10500	2177418..2179082	-	1665	WP_027675448.1	electron transfer flavoprotein-ubiquinone oxidoreductase	-
CFBP5473_RS10505	2179393..2180787	+	1395	WP_027675449.1	FAD-binding oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA (3-130)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11165.86 Da
• Isoelectric Point: 6.9886

>T124198 WP_027675444.1 NZ_CP039691:2175184-2175480 [Agrobacterium larrymoorei]
MEKTAPHTVLEDVWRLLDEGKVRETFSALSGAAALGMSRSDMHDVVRALSLKDFFKSMTAYHDENVWHDVYKPVTPFGHL
YVKLIVSNNVLIVSFKEK

Nucleotide

• Length: 297 bp

>T124198 NZ_CP039691:2175184-2175480 [Agrobacterium larrymoorei]
ATGGAAAAGACCGCGCCGCATACTGTGCTCGAAGATGTATGGCGATTATTGGATGAAGGCAAAGTCAGGGAAACATTCTC
AGCCTTGAGCGGAGCCGCGGCTCTCGGCATGTCGCGGAGTGATATGCATGACGTCGTACGTGCCCTAAGCCTCAAGGATT
TCTTCAAATCCATGACGGCTTACCACGACGAGAATGTCTGGCATGATGTCTATAAACCGGTGACGCCCTTCGGGCATCTA
TATGTAAAACTGATCGTATCGAACAACGTATTGATCGTGTCGTTCAAGGAGAAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14521.51 Da
• Isoelectric Point: 5.2501

>AT124198 WP_027675445.1 NZ_CP039691:2175482-2175883 [Agrobacterium larrymoorei]
MACPICGADAVTKETRDLEYSYKGQVTTIPHVTGTFCSACGEAILEGEESERVSAAMLAFNRQVNASFVDPEFIATVRKK
LSLDQREAGDLFGGGVNAFSRYENGKSRPPRSLIQLLKILEKHPDLLDEIKAA

Nucleotide

• Length: 402 bp

>AT124198 NZ_CP039691:2175482-2175883 [Agrobacterium larrymoorei]
ATGGCTTGCCCTATTTGCGGCGCTGATGCCGTGACGAAGGAAACGCGCGATCTTGAATATTCCTATAAAGGACAAGTCAC
GACCATTCCTCATGTAACGGGCACATTTTGCAGCGCTTGCGGCGAAGCCATACTGGAAGGCGAAGAGAGCGAACGCGTGA
GCGCCGCGATGCTCGCTTTCAACAGACAGGTCAATGCGAGCTTTGTCGACCCGGAATTTATAGCGACGGTGCGCAAAAAG
CTTTCGCTGGACCAGCGGGAAGCAGGCGATCTTTTCGGCGGTGGCGTGAACGCCTTCTCGCGTTACGAGAACGGCAAATC
ACGCCCGCCGCGCTCCCTTATTCAGTTGCTCAAGATATTGGAGAAGCACCCCGACCTGCTGGACGAAATCAAGGCTGCCT
GA

Structures

Toxin

• AlphaFold DB: A0A4D7DRI6

Antitoxin

• AlphaFold DB: A0A4D7DPV9