Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 298941..299523 Replicon chromosome
Accession NZ_CP039648
Organism Azospirillum sp. TSA2s

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E6C67_RS15585 Protein ID WP_136703203.1
Coordinates 298941..299219 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E6C67_RS15590 Protein ID WP_136703204.1
Coordinates 299236..299523 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E6C67_RS15570 294925..295302 - 378 WP_109074679.1 hypothetical protein -
E6C67_RS15575 295508..296023 + 516 WP_136703201.1 ribonuclease E activity regulator RraA -
E6C67_RS15580 296226..298817 + 2592 WP_136703202.1 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase -
E6C67_RS15585 298941..299219 + 279 WP_136703203.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E6C67_RS15590 299236..299523 + 288 WP_136703204.1 HigA family addiction module antidote protein Antitoxin
E6C67_RS15595 299564..300469 - 906 WP_136703205.1 MBL fold metallo-hydrolase -
E6C67_RS15600 300551..301327 - 777 WP_136703206.1 SDR family oxidoreductase -
E6C67_RS15605 301355..302884 - 1530 WP_136703207.1 tripartite tricarboxylate transporter permease -
E6C67_RS15610 302936..303472 - 537 WP_136703208.1 tripartite tricarboxylate transporter TctB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10674.15 Da        Isoelectric Point: 9.0052

>T124186 WP_136703203.1 NZ_CP039648:298941-299219 [Azospirillum sp. TSA2s]
MIRSFRDRRTKALYDGEAVRQFGAISKVAVRKLDMLNAAAVLEDLRSPPGNRLEALRGDRAGQHSIRINDQWRVCFVWRE
DGVYEVEIVDYH

Download         Length: 279 bp

>T124186 NZ_CP039648:298941-299219 [Azospirillum sp. TSA2s]
ATGATACGCAGTTTCCGTGATCGGCGAACCAAGGCGCTGTATGACGGCGAAGCCGTCCGTCAGTTCGGTGCCATCTCCAA
AGTCGCTGTTCGGAAACTGGACATGCTGAACGCTGCGGCAGTGTTGGAGGATTTGCGTTCGCCACCGGGGAACCGACTGG
AAGCGCTCAGAGGAGATCGAGCTGGGCAGCATAGCATCCGCATCAACGACCAATGGCGTGTCTGCTTCGTCTGGCGCGAG
GACGGCGTCTACGAGGTGGAGATCGTTGATTACCATTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10545.95 Da        Isoelectric Point: 6.4829

>AT124186 WP_136703204.1 NZ_CP039648:299236-299523 [Azospirillum sp. TSA2s]
MRVKTHPGEVLREEFMEPLGLTANALSIALRVPATRIGEIVNERRGISADTALRLARYFGTTPQFWLNLQSDHDLSVAAS
EHGAEIERDVHPRAA

Download         Length: 288 bp

>AT124186 NZ_CP039648:299236-299523 [Azospirillum sp. TSA2s]
ATGCGCGTCAAAACACATCCCGGCGAAGTCCTGCGGGAGGAATTCATGGAGCCGCTGGGGCTGACGGCCAATGCGCTGTC
CATTGCTCTGCGTGTTCCCGCCACCCGGATTGGCGAGATCGTCAACGAACGTCGGGGCATCAGTGCCGACACCGCCTTAC
GCCTTGCCCGTTACTTCGGCACCACGCCACAATTCTGGCTGAACCTGCAGTCCGACCATGACCTGTCGGTTGCCGCCAGC
GAGCATGGCGCGGAGATCGAACGCGACGTCCATCCCCGCGCAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References