Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 103103..103760 | Replicon | plasmid PNCS014847 strain 14[5]12:i:- |
| Accession | NZ_CP039562 | ||
| Organism | Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain PNCS014847 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | E5N88_RS25340 | Protein ID | WP_000270043.1 |
| Coordinates | 103410..103760 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | E5N88_RS25335 | Protein ID | WP_000124640.1 |
| Coordinates | 103103..103405 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E5N88_RS25285 | 98728..99156 | + | 429 | WP_000591074.1 | hypothetical protein | - |
| E5N88_RS25290 | 99213..99572 | + | 360 | WP_000422768.1 | hypothetical protein | - |
| E5N88_RS25295 | 99572..100018 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| E5N88_RS25300 | 100015..100533 | + | 519 | WP_000210756.1 | nitrite reductase | - |
| E5N88_RS25305 | 100533..100763 | + | 231 | WP_000972663.1 | hypothetical protein | - |
| E5N88_RS25310 | 100750..101607 | + | 858 | WP_001167032.1 | hypothetical protein | - |
| E5N88_RS25315 | 101675..101821 | + | 147 | WP_014342196.1 | hypothetical protein | - |
| E5N88_RS25320 | 101838..102365 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
| E5N88_RS25325 | 102423..102695 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| E5N88_RS25330 | 102783..103076 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| E5N88_RS25335 | 103103..103405 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| E5N88_RS25340 | 103410..103760 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| E5N88_RS25345 | 103923..104471 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
| E5N88_RS25980 | 104593..104784 | - | 192 | WP_014342197.1 | hypothetical protein | - |
| E5N88_RS25355 | 104812..105006 | + | 195 | WP_000343597.1 | hypothetical protein | - |
| E5N88_RS25360 | 105017..105388 | + | 372 | WP_000516916.1 | hypothetical protein | - |
| E5N88_RS25365 | 105381..105851 | + | 471 | WP_001281821.1 | hypothetical protein | - |
| E5N88_RS25370 | 105866..106201 | - | 336 | WP_000683476.1 | hypothetical protein | - |
| E5N88_RS25375 | 106298..106786 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| E5N88_RS25380 | 106789..107286 | + | 498 | WP_000062185.1 | hypothetical protein | - |
| E5N88_RS25390 | 107501..108205 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| E5N88_RS25395 | 108270..108449 | - | 180 | Protein_139 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..178506 | 178506 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 17237.68 Da Isoelectric Point: 5.5500
>T124157 WP_000270043.1 NZ_CP039562:c103760-103410 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 351 bp
>T124157 NZ_CP039562:c103760-103410 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
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Antitoxin
Download Length: 101 a.a. Molecular weight: 14882.85 Da Isoelectric Point: 5.5500
>AT124157 WP_000124640.1 NZ_CP039562:c103405-103103 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
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Download Length: 303 bp
>AT124157 NZ_CP039562:c103405-103103 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|