Detailed information of TA system TA124145

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 3102218..3102603
• Replicon: chromosome
• Accession: NZ_CP039549
• Organism: Enterococcus faecalis strain VE18395

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U3MBY2
• Locus tag: FAJ55_RS16440
• Protein ID: WP_002372618.1
• Coordinates: 3102218..3102415 (+)
• Length: 66 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	3102348..3102603 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FAJ55_RS16415	3097695..3098327	-	633	WP_002358972.1	RloB family protein	-
FAJ55_RS16420	3098336..3099631	-	1296	WP_002379013.1	AAA family ATPase	-
FAJ55_RS16435	3100093..3101709	+	1617	WP_002379014.1	phosphatase PAP2/LCP family protein	-
FAJ55_RS16440	3102218..3102415	+	198	WP_002372618.1	putative holin-like toxin	Toxin
-	3102348..3102603	-	256	-	-	Antitoxin
FAJ55_RS16445	3102605..3106363	-	3759	WP_010706868.1	WxL domain-containing protein	-
FAJ55_RS16450	3106959..3107102	+	144	WP_002387585.1	putative holin-like toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (32-65)

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7516.13 Da
• Isoelectric Point: 10.5649

>T124145 WP_002372618.1 NZ_CP039549:3102218-3102415 [Enterococcus faecalis]
MCREVMAVAIQSEREVMRMHVFPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 198 bp

>T124145 NZ_CP039549:3102218-3102415 [Enterococcus faecalis]
ATGTGTAGAGAAGTTATGGCGGTGGCTATCCAATCTGAAAGAGAGGTGATGCGTATGCACGTATTTCCGAAATTCACAGA
AAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGGTATGTTTACCATTGCTTTGATTGCGC
TGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 256 bp

>AT124145 NZ_CP039549:c3102603-3102348 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTTGAAATAGGAGGCTCAGGCATTTTTTATTGATGGTCTTTTTAGGGTTGTTGTGCTATAATGA
TAAAGAAAAGAGAGATATGCTTCCAACATATCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCAATTTTATTATTTAAA
AATAACCGTGCTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAAAGCA
ATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A4U3MBY2

Antitoxin