Detailed information of TA system TA124135

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2945270..2945554
• Replicon: chromosome
• Accession: NZ_CP039549
• Organism: Enterococcus faecalis strain VE18395

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: FAJ55_RS15660
• Protein ID: WP_002386265.1
• Coordinates: 2945426..2945554 (-)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2945270..2945477 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FAJ55_RS15635	2940954..2941907	-	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-
FAJ55_RS15640	2941946..2942701	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
FAJ55_RS15645	2942698..2943663	-	966	WP_002387376.1	iron chelate uptake ABC transporter family permease subunit	-
FAJ55_RS15650	2943660..2944607	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
FAJ55_RS15655	2944792..2945244	+	453	WP_002378959.1	YueI family protein	-
-	2945270..2945477	+	208	-	-	Antitoxin
FAJ55_RS15660	2945426..2945554	-	129	WP_002386265.1	hypothetical protein	Toxin
FAJ55_RS15665	2945860..2945989	-	130	Protein_2855	putative holin-like toxin	-
FAJ55_RS15670	2946152..2948422	-	2271	WP_002399785.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
FAJ55_RS15675	2948593..2949093	+	501	WP_002378961.1	cysteine hydrolase	-
FAJ55_RS15680	2949654..2950550	+	897	WP_002354953.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4742.66 Da
• Isoelectric Point: 7.0058

>T124135 WP_002386265.1 NZ_CP039549:c2945554-2945426 [Enterococcus faecalis]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 129 bp

>T124135 NZ_CP039549:c2945554-2945426 [Enterococcus faecalis]
ATGCACTTTAACGAAAGGAGCATTTTTTTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGC
ACTACTGATTTTCGGTATCCTTGAAGCAACGAAAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 208 bp

>AT124135 NZ_CP039549:2945270-2945477 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTAT
TTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin