Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 3118797..3119229 Replicon chromosome
Accession NZ_CP039548
Organism Enterococcus faecalis strain VE18379

Toxin (Protein)


Gene name txpA Uniprot ID A0A4U3MBY2
Locus tag FAJ42_RS16505 Protein ID WP_002372618.1
Coordinates 3119032..3119229 (+) Length 66 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 3118797..3118973 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FAJ42_RS16480 3114509..3115141 - 633 WP_002358972.1 RloB family protein -
FAJ42_RS16485 3115150..3116445 - 1296 WP_002379013.1 AAA family ATPase -
FAJ42_RS16500 3116907..3118523 + 1617 WP_002379014.1 phosphatase PAP2/LCP family protein -
- 3118797..3118973 - 177 - - Antitoxin
FAJ42_RS16505 3119032..3119229 + 198 WP_002372618.1 putative holin-like toxin Toxin
FAJ42_RS16510 3119419..3123177 - 3759 WP_010706868.1 WxL domain-containing protein -
FAJ42_RS16515 3123773..3123916 + 144 WP_002387585.1 putative holin-like toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(32-65)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7516.13 Da        Isoelectric Point: 10.5649

>T124116 WP_002372618.1 NZ_CP039548:3119032-3119229 [Enterococcus faecalis]
MCREVMAVAIQSEREVMRMHVFPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Download         Length: 198 bp

>T124116 NZ_CP039548:3119032-3119229 [Enterococcus faecalis]
ATGTGTAGAGAAGTTATGGCGGTGGCTATCCAATCTGAAAGAGAGGTGATGCGTATGCACGTATTTCCGAAATTCACAGA
AAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGGTATGTTTACCATTGCTTTGATTGCGC
TGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 177 bp

>AT124116 NZ_CP039548:c3118973-3118797 [Enterococcus faecalis]
TGTGCTATAATAGCAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCGGTTTAAGACGGTGACCTTTT
GGATTATTTAAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCTTCTTTAACAGCTTTTAGGATTCCG
AAGATTAACGTTGCGAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U3MBY2

Antitoxin

Download structure file

References