Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2907293..2907898 Replicon chromosome
Accession NZ_CP039546
Organism Methylorubrum populi strain YC-XJ1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E8E01_RS13630 Protein ID WP_141951735.1
Coordinates 2907617..2907898 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E8E01_RS13625 Protein ID WP_141951734.1
Coordinates 2907293..2907586 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8E01_RS13595 2902914..2903129 - 216 WP_141951728.1 hypothetical protein -
E8E01_RS13600 2903350..2904087 + 738 WP_141951729.1 cell wall hydrolase -
E8E01_RS13605 2904222..2905226 + 1005 WP_141951730.1 lipoyl synthase -
E8E01_RS13610 2905233..2905691 + 459 WP_141951731.1 type II toxin-antitoxin system RatA family toxin -
E8E01_RS13615 2905692..2906117 - 426 WP_141951732.1 Lrp/AsnC family transcriptional regulator -
E8E01_RS13620 2906159..2907280 + 1122 WP_210244216.1 ornithine cyclodeaminase -
E8E01_RS13625 2907293..2907586 - 294 WP_141951734.1 HigA family addiction module antidote protein Antitoxin
E8E01_RS13630 2907617..2907898 - 282 WP_141951735.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E8E01_RS13635 2907984..2908307 - 324 WP_141951736.1 phosphotyrosine protein phosphatase -
E8E01_RS13640 2908304..2910091 - 1788 WP_141951737.1 ABC transporter ATP-binding protein/permease -
E8E01_RS13645 2910722..2911216 + 495 WP_141951738.1 (2Fe-2S)-binding protein -
E8E01_RS13650 2911213..2912262 + 1050 WP_141951739.1 xanthine dehydrogenase family protein subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-67)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11027.40 Da        Isoelectric Point: 7.8572

>T124100 WP_141951735.1 NZ_CP039546:c2907898-2907617 [Methylorubrum populi]
MIQSFADKRTRSLFEEGVCHRQWRAFERTARRKLDALDYAVVLDDLRSPPGNKLEALRGDRAGQYSIRINDQWRICFRWT
ESGPENVEIVDYH

Download         Length: 282 bp

>T124100 NZ_CP039546:c2907898-2907617 [Methylorubrum populi]
ATGATTCAAAGCTTCGCCGACAAGCGCACACGCTCTCTGTTCGAGGAAGGCGTCTGCCACCGTCAGTGGCGCGCCTTCGA
GCGAACTGCTCGGCGGAAGCTTGATGCTTTGGACTACGCCGTCGTGCTGGACGATCTGCGCAGCCCGCCGGGCAACAAGC
TTGAGGCTTTGCGCGGGGACAGAGCGGGGCAGTACAGCATTCGCATCAACGATCAGTGGCGGATTTGTTTCCGGTGGACT
GAGTCAGGCCCGGAGAATGTCGAGATCGTCGATTATCATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10953.45 Da        Isoelectric Point: 10.1335

>AT124100 WP_141951734.1 NZ_CP039546:c2907586-2907293 [Methylorubrum populi]
MIRVRTHPGEYLSEEYLKPLGLSARQLAVEIGVPANRITEIVRQRRGITADTALRLARYFGTTPQFWLNFQAGYDLSKAQ
AETDYSTVPRRRAADAA

Download         Length: 294 bp

>AT124100 NZ_CP039546:c2907586-2907293 [Methylorubrum populi]
ATGATTCGAGTTCGGACGCATCCTGGCGAGTACTTGTCGGAAGAATACCTCAAACCACTCGGTCTCAGTGCCCGCCAGCT
CGCGGTCGAGATCGGTGTTCCAGCCAACCGCATCACCGAGATCGTTCGGCAGCGGCGCGGCATCACCGCAGATACGGCGC
TTCGTCTTGCACGCTACTTCGGGACAACCCCGCAGTTCTGGCTCAATTTTCAAGCCGGCTACGATCTCTCCAAGGCCCAG
GCGGAAACGGACTACTCAACTGTTCCACGGCGGCGAGCCGCCGACGCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References