Detailed information of TA system TA124061

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 1372432..1373032
• Replicon: chromosome
• Accession: NZ_CP039516
• Organism: Salinivibrio sp. YCSC6

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: E8E00_RS06305
• Protein ID: WP_096628526.1
• Coordinates: 1372709..1373032 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A2A4GFS1
• Locus tag: E8E00_RS06300
• Protein ID: WP_069587053.1
• Coordinates: 1372432..1372716 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E8E00_RS06285	1367576..1368742	+	1167	WP_168174033.1	DnaJ domain-containing protein	-
E8E00_RS06290	1368863..1370026	+	1164	WP_096628530.1	hypothetical protein	-
E8E00_RS06295	1370348..1370632	-	285	WP_069587016.1	TIGR03643 family protein	-
E8E00_RS06300	1372432..1372716	-	285	WP_069587053.1	helix-turn-helix domain-containing protein	Antitoxin
E8E00_RS06305	1372709..1373032	-	324	WP_096628526.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E8E00_RS06310	1373287..1374258	+	972	WP_096628524.1	type I-F CRISPR-associated endonuclease Cas1	-
E8E00_RS06315	1374255..1377629	+	3375	WP_096628522.1	type I-F CRISPR-associated helicase Cas3	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (15-101)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-87)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12096.17 Da
• Isoelectric Point: 9.9067

>T124061 WP_096628526.1 NZ_CP039516:c1373032-1372709 [Salinivibrio sp. YCSC6]
MHWNIVFYRGVEESILNMPPKIQARMLKLLELIEKHGANLGPPHTESLGDGLFEIRAKAKEGIGRSLFCDLDGPNIYVLH
AFVKKSQKTPKKDLALATGRMREVKNE

Nucleotide

• Length: 324 bp

>T124061 NZ_CP039516:c1373032-1372709 [Salinivibrio sp. YCSC6]
ATGCACTGGAATATTGTTTTTTATCGAGGCGTAGAAGAGAGCATTCTCAACATGCCTCCTAAGATTCAAGCGCGAATGCT
CAAGCTGCTTGAATTAATAGAAAAACATGGCGCAAATTTAGGCCCTCCTCACACAGAATCATTAGGTGACGGCCTGTTTG
AAATTCGCGCCAAAGCAAAAGAAGGGATCGGGCGAAGTCTATTCTGTGATTTAGACGGTCCCAACATCTATGTCCTTCAT
GCATTTGTGAAGAAAAGCCAAAAGACACCAAAGAAAGACTTAGCATTGGCAACAGGGCGTATGAGAGAGGTGAAAAATGA
ATAG

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10559.17 Da
• Isoelectric Point: 9.8481

>AT124061 WP_069587053.1 NZ_CP039516:c1372716-1372432 [Salinivibrio sp. YCSC6]
MNSLQALKARALQNPDVKQAYDELTPEFELIDMLLSMRKQAGLTQQQVAERMGTKEGNISRLEKGKGNPTVKTLFNYAKA
CNCKLNFGYKHAPN

Nucleotide

• Length: 285 bp

>AT124061 NZ_CP039516:c1372716-1372432 [Salinivibrio sp. YCSC6]
ATGAATAGCTTACAGGCATTAAAAGCGAGAGCATTACAAAACCCAGACGTGAAACAAGCATACGATGAATTGACGCCTGA
GTTTGAATTGATCGATATGTTACTCAGTATGCGTAAGCAGGCCGGGCTAACTCAACAGCAGGTTGCAGAACGTATGGGGA
CGAAAGAAGGCAATATTTCTCGACTTGAAAAAGGGAAAGGCAATCCAACCGTTAAAACCCTGTTTAACTATGCAAAAGCA
TGCAATTGCAAGCTTAACTTTGGCTACAAACATGCGCCAAATTAA

Structures

Antitoxin

• AlphaFold DB: A0A2A4GFS1