Detailed information of TA system TA124060

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4532089..4532691
• Replicon: chromosome
• Accession: NZ_CP039502
• Organism: Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000189

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: SEEB0189_RS22250
• Protein ID: WP_001159635.1
• Coordinates: 4532380..4532691 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: SEEB0189_RS22245
• Protein ID: WP_000362050.1
• Coordinates: 4532089..4532379 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SEEB0189_RS22230 (4529582)	4529582..4530484	+	903	WP_000331362.1	formate dehydrogenase subunit beta	-
SEEB0189_RS22235 (4530481)	4530481..4531116	+	636	WP_000829028.1	formate dehydrogenase cytochrome b556 subunit	-
SEEB0189_RS22240 (4531113)	4531113..4532042	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
SEEB0189_RS22245 (4532089)	4532089..4532379	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
SEEB0189_RS22250 (4532380)	4532380..4532691	-	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
SEEB0189_RS22255 (4532909)	4532909..4533823	+	915	WP_020839733.1	alpha/beta hydrolase	-
SEEB0189_RS22260 (4533849)	4533849..4534790	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
SEEB0189_RS22265 (4534835)	4534835..4535272	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
SEEB0189_RS22270 (4535269)	4535269..4536141	-	873	WP_000921423.1	virulence factor BrkB family protein	-
SEEB0189_RS22275 (4536135)	4536135..4536734	-	600	WP_001621364.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T124060 WP_001159635.1 NZ_CP039502:c4532691-4532380 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T124060 NZ_CP039502:c4532691-4532380 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT124060 WP_000362050.1 NZ_CP039502:c4532379-4532089 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT124060 NZ_CP039502:c4532379-4532089 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAGATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A3V2JK97