124043

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 362226..362764 Replicon chromosome
Accession NZ_CP039502
Organism Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000189

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag SEEB0189_RS02085 Protein ID WP_001526148.1
Coordinates 362489..362764 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag SEEB0189_RS02080 Protein ID WP_000729713.1
Coordinates 362226..362486 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SEEB0189_RS02065 (357968) 357968..359521 + 1554 WP_020838974.1 TROVE domain-containing protein -
SEEB0189_RS02070 (359880) 359880..361094 + 1215 WP_001105529.1 RNA-splicing ligase RtcB -
SEEB0189_RS02075 (361098) 361098..362117 + 1020 WP_020838976.1 RNA 3'-terminal phosphate cyclase -
SEEB0189_RS02080 (362226) 362226..362486 + 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
SEEB0189_RS02085 (362489) 362489..362764 + 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
SEEB0189_RS02090 (362852) 362852..365557 - 2706 WP_000907030.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T124043 WP_001526148.1 NZ_CP039502:362489-362764 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T124043 NZ_CP039502:362489-362764 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT124043 WP_000729713.1 NZ_CP039502:362226-362486 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT124043 NZ_CP039502:362226-362486 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References