Detailed information of TA system TA124012

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 2072756..2073275
• Replicon: chromosome
• Accession: NZ_CP039462
• Organism: Streptococcus suis strain WUSS351

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: E8M06_RS10080
• Protein ID: WP_136581611.1
• Coordinates: 2072756..2073013 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A0Z8KP98
• Locus tag: E8M06_RS10085
• Protein ID: WP_044763722.1
• Coordinates: 2073015..2073275 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E8M06_RS10070	2069836..2071566	-	1731	WP_168800261.1	hypothetical protein	-
E8M06_RS10075	2071769..2072641	-	873	WP_105183622.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
E8M06_RS10080	2072756..2073013	-	258	WP_136581611.1	Txe/YoeB family addiction module toxin	Toxin
E8M06_RS10085	2073015..2073275	-	261	WP_044763722.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E8M06_RS10090	2073947..2074401	-	455	Protein_1908	8-oxo-dGTP diphosphatase	-
E8M06_RS10095	2074421..2074939	-	519	WP_136581612.1	DUF3916 domain-containing protein	-
E8M06_RS10100	2074936..2075538	-	603	WP_168800262.1	ribonuclease M5	-
E8M06_RS10105	2075501..2076283	-	783	WP_136581614.1	TatD family hydrolase	-
E8M06_RS10110	2076389..2076526	-	138	WP_002939016.1	50S ribosomal protein L34	-
E8M06_RS10115	2076694..2077689	-	996	WP_013730624.1	protein jag	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10261.79 Da
• Isoelectric Point: 8.0266

>T124012 WP_136581611.1 NZ_CP039462:c2073013-2072756 [Streptococcus suis]
MGIHFTEDAWEDYLYWKGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYG

Nucleotide

• Length: 258 bp

>T124012 NZ_CP039462:c2073013-2072756 [Streptococcus suis]
ATGGGAATCCATTTTACAGAGGATGCTTGGGAAGACTATCTTTATTGGAAAGGTCAGGATAAGAAAACGCTGAAGAGAAT
CAATAAAATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCTTGGTCAAGGAGGATTGATGCGGAGAATCGGTTGATTTATATGGTGGAGGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGACCATTATGGGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9980.32 Da
• Isoelectric Point: 5.1255

>AT124012 WP_044763722.1 NZ_CP039462:c2073275-2073015 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLTVARNTYLSQKVLRGMAQVKAGQTQER
NLIEAD

Nucleotide

• Length: 261 bp

>AT124012 NZ_CP039462:c2073275-2073015 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGATGAGTTTGAGCCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGCGAGTGGGATAGTTTACAAGAAACCCTCA
CTGTTGCTCGGAACACCTATCTGTCTCAAAAAGTTTTGCGTGGTATGGCTCAAGTCAAAGCAGGGCAAACCCAAGAACGA
AACCTGATAGAGGCCGACTAG

Structures

Antitoxin

• AlphaFold DB: A0A0Z8KP98