Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3907923..3908650 Replicon chromosome
Accession NZ_CP039453
Organism Enterobacter bugandensis strain 220

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FBF69_RS19070 Protein ID WP_136486439.1
Coordinates 3907923..3908234 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FBF69_RS19075 Protein ID WP_136486441.1
Coordinates 3908231..3908650 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FBF69_RS19050 3903123..3903902 - 780 WP_028012263.1 acetolactate decarboxylase -
FBF69_RS19055 3904008..3904889 + 882 WP_048998942.1 LysR family transcriptional regulator -
FBF69_RS19060 3905083..3905538 + 456 WP_047367676.1 hypothetical protein -
FBF69_RS19065 3905944..3907506 - 1563 WP_136486437.1 HD domain-containing protein -
FBF69_RS19070 3907923..3908234 + 312 WP_136486439.1 type II toxin-antitoxin system HigB family toxin Toxin
FBF69_RS19075 3908231..3908650 + 420 WP_136486441.1 helix-turn-helix domain-containing protein Antitoxin
FBF69_RS19080 3908702..3908845 - 144 WP_136486443.1 2-dehydropantoate 2-reductase -
FBF69_RS19085 3909288..3909779 + 492 WP_136486445.1 Hcp family type VI secretion system effector -
FBF69_RS19090 3909790..3910146 + 357 WP_045325586.1 DUF2778 domain-containing protein -
FBF69_RS19095 3910143..3910577 + 435 WP_136486447.1 hypothetical protein -
FBF69_RS19100 3910629..3911519 - 891 WP_136486449.1 oxidoreductase -
FBF69_RS19105 3911624..3912745 + 1122 WP_047367655.1 glutamate--cysteine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-134)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12434.22 Da        Isoelectric Point: 10.1702

>T123999 WP_136486439.1 NZ_CP039453:3907923-3908234 [Enterobacter bugandensis]
MHVVSRAPFDTAARHFPNQSLALDDLYRVLKKEHYSSPDDMRKRFPSLDRMKYREKWWVIDVGGGHLRVIFFADFERGKI
FIKHISTHANYDKLTDYYRRTKE

Download         Length: 312 bp

>T123999 NZ_CP039453:3907923-3908234 [Enterobacter bugandensis]
ATGCACGTAGTCTCAAGAGCGCCTTTCGACACAGCAGCCAGACACTTTCCCAACCAATCACTCGCCCTGGACGATCTTTA
CCGTGTACTAAAGAAGGAACACTACTCGTCACCAGACGACATGCGAAAGCGGTTCCCCAGCCTGGACAGGATGAAATACC
GGGAAAAATGGTGGGTCATTGATGTGGGAGGCGGGCATTTAAGAGTGATATTTTTTGCTGATTTTGAGCGGGGAAAGATC
TTCATCAAACACATCAGCACTCACGCAAACTATGACAAGCTCACGGATTACTACCGGAGAACGAAAGAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15465.55 Da        Isoelectric Point: 4.6051

>AT123999 WP_136486441.1 NZ_CP039453:3908231-3908650 [Enterobacter bugandensis]
MNYAAAIKAANALTNELPFLGSSPSRQDYEDALAMVEYLIEHDPDNPLVDMLTAKIDKYENESPEFAEFNARIASIPSGV
ALLRTLMDQYQLTQSDFENEIGKKSLVSRILNGQRTLTLEHMRALAKRFGLPVSAFVGN

Download         Length: 420 bp

>AT123999 NZ_CP039453:3908231-3908650 [Enterobacter bugandensis]
ATGAATTATGCAGCAGCCATCAAAGCGGCAAACGCTCTGACAAACGAGCTCCCTTTCCTGGGTTCAAGCCCGTCGCGACA
AGACTACGAGGATGCGCTGGCAATGGTGGAGTATCTGATCGAGCACGACCCCGATAACCCGCTCGTAGACATGCTCACCG
CCAAAATCGATAAGTACGAAAACGAGTCTCCCGAGTTTGCAGAATTTAACGCACGTATTGCCAGCATTCCGTCAGGCGTT
GCGTTATTGCGAACGCTGATGGATCAGTACCAACTCACTCAGAGCGATTTCGAGAACGAGATTGGTAAGAAGTCTCTGGT
GAGTCGGATCCTGAATGGACAGCGCACGTTAACGCTGGAGCATATGCGAGCGCTGGCGAAGCGTTTTGGTTTGCCGGTGA
GTGCGTTTGTGGGGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References