Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1469457..1470059 Replicon chromosome
Accession NZ_CP039452
Organism Enterobacter bugandensis strain 1367

Toxin (Protein)


Gene name higB Uniprot ID A0A167J774
Locus tag FBF68_RS07085 Protein ID WP_047366784.1
Coordinates 1469457..1469768 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A167J796
Locus tag FBF68_RS07090 Protein ID WP_047366785.1
Coordinates 1469769..1470059 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FBF68_RS07055 1465116..1465859 + 744 WP_063155520.1 winged helix-turn-helix domain-containing protein -
FBF68_RS07060 1465856..1466326 + 471 WP_063155519.1 hypothetical protein -
FBF68_RS07065 1466414..1467013 + 600 WP_045260234.1 glucose-1-phosphatase -
FBF68_RS07070 1467007..1467888 + 882 WP_045260235.1 virulence factor BrkB family protein -
FBF68_RS07075 1467885..1468322 + 438 WP_008501836.1 D-tyrosyl-tRNA(Tyr) deacylase -
FBF68_RS07080 1468367..1469308 + 942 WP_028014875.1 fatty acid biosynthesis protein FabY -
FBF68_RS07085 1469457..1469768 + 312 WP_047366784.1 hypothetical protein Toxin
FBF68_RS07090 1469769..1470059 + 291 WP_047366785.1 helix-turn-helix domain-containing protein Antitoxin
FBF68_RS07095 1470101..1471030 - 930 WP_028014872.1 formate dehydrogenase accessory protein FdhE -
FBF68_RS07100 1471027..1471662 - 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
FBF68_RS07105 1471659..1472561 - 903 WP_003861960.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12135.13 Da        Isoelectric Point: 8.8415

>T123974 WP_047366784.1 NZ_CP039452:1469457-1469768 [Enterobacter bugandensis]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPEYGDVIQNTGGLRKIRWLAGGKGKRGGVRVIYFYRTCEFEIRLLLIY
RKGIKDDLSAGEKAILKKMIERW

Download         Length: 312 bp

>T123974 NZ_CP039452:1469457-1469768 [Enterobacter bugandensis]
ATGCTATTCATTGAAACGGACATTTTCACAGAAGACGTCAAAACGTTACTGGATGACGACGAATATCATCGGTTCCAGAT
ATTCCTGGCGACACAACCGGAGTACGGCGATGTTATCCAGAATACGGGAGGCTTGCGAAAGATTCGCTGGCTTGCTGGCG
GAAAGGGAAAGCGTGGTGGAGTCAGAGTTATCTATTTTTACCGTACGTGTGAGTTTGAAATCAGACTGCTGCTCATCTAT
CGCAAAGGGATTAAAGATGACCTGTCTGCGGGGGAGAAAGCTATTCTGAAAAAGATGATAGAGAGGTGGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10674.22 Da        Isoelectric Point: 10.5888

>AT123974 WP_047366785.1 NZ_CP039452:1469769-1470059 [Enterobacter bugandensis]
MDKALFERLTQSVGQMNEIAEGQREPSRIFQIDAMKIKEIRQASGLSQSKFATLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp

>AT123974 NZ_CP039452:1469769-1470059 [Enterobacter bugandensis]
ATGGATAAGGCGCTGTTTGAGCGATTAACCCAAAGCGTTGGGCAAATGAACGAGATTGCCGAGGGCCAACGCGAGCCGTC
GCGTATCTTTCAAATCGATGCGATGAAAATAAAAGAAATTCGTCAGGCATCCGGGTTGTCGCAGAGTAAATTCGCGACCT
TAATCTCTGTCAGCGTTGATACATTGCGTAACTGGGAACAAGGCAGACGCTCGCCTACAGGCCCGGCTAAAGCGCTTTTG
CGCGCTATTGCTAACGATCCTCAACATGTCATCCCTGCGCTATCGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A167J774

Antitoxin

Source ID Structure
AlphaFold DB A0A167J796

References