Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2509374..2509558 Replicon chromosome
Accession NZ_CP039448
Organism Staphylococcus aureus strain VGC1

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag E8M03_RS12750 Protein ID WP_000482647.1
Coordinates 2509451..2509558 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2509374..2509434 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8M03_RS12735 2504884..2505051 - 168 WP_031845053.1 hypothetical protein -
E8M03_RS12740 2505282..2507015 - 1734 WP_000488493.1 ABC transporter ATP-binding protein/permease -
E8M03_RS12745 2507091..2508803 - 1713 WP_001064821.1 ABC transporter ATP-binding protein/permease -
E8M03_RS14745 2509257..2509424 - 168 WP_000301893.1 hypothetical protein -
- 2509374..2509434 + 61 - - Antitoxin
E8M03_RS12750 2509451..2509558 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
E8M03_RS12755 2509691..2510077 - 387 WP_000779353.1 flippase GtxA -
E8M03_RS12760 2510345..2511487 + 1143 WP_001176863.1 glycerate kinase -
E8M03_RS12765 2511547..2512206 + 660 WP_000831298.1 membrane protein -
E8M03_RS12770 2512389..2513600 + 1212 WP_001191921.1 multidrug effflux MFS transporter -
E8M03_RS12775 2513723..2514196 - 474 WP_000456483.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T123968 WP_000482647.1 NZ_CP039448:c2509558-2509451 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T123968 NZ_CP039448:c2509558-2509451 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT123968 NZ_CP039448:2509374-2509434 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References