Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2484103..2484620 Replicon chromosome
Accession NZ_CP039448
Organism Staphylococcus aureus strain VGC1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag E8M03_RS12610 Protein ID WP_000113263.1
Coordinates 2484103..2484369 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E8M03_RS12615 Protein ID WP_000584499.1
Coordinates 2484369..2484620 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8M03_RS12585 2479363..2479899 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
E8M03_RS12590 2480312..2481136 - 825 WP_000594633.1 formate/nitrite transporter family protein -
E8M03_RS12595 2481340..2481522 - 183 WP_000079140.1 hypothetical protein -
E8M03_RS12600 2481609..2482076 - 468 WP_000153338.1 SRPBCC domain-containing protein -
E8M03_RS12605 2482262..2483809 - 1548 WP_000727757.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E8M03_RS12610 2484103..2484369 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
E8M03_RS12615 2484369..2484620 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E8M03_RS12620 2484793..2484884 - 92 Protein_2400 hypothetical protein -
E8M03_RS12625 2484891..2485490 - 600 WP_000162810.1 DsbA family protein -
E8M03_RS12630 2485509..2485871 - 363 WP_000819839.1 DUF4467 domain-containing protein -
E8M03_RS12635 2486126..2487376 + 1251 WP_001012236.1 FemA/FemB family glycyltransferase FmhA -
E8M03_RS12640 2487473..2488204 - 732 WP_149569703.1 amino acid ABC transporter ATP-binding protein -
E8M03_RS12645 2488201..2488920 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T123967 WP_000113263.1 NZ_CP039448:c2484369-2484103 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T123967 NZ_CP039448:c2484369-2484103 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGTTATTATAGTAGACGTATCAATCACGAACATAGATTGGTCTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT123967 WP_000584499.1 NZ_CP039448:c2484620-2484369 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT123967 NZ_CP039448:c2484620-2484369 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACCTCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGAAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References