Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2222776..2223039 Replicon chromosome
Accession NZ_CP039448
Organism Staphylococcus aureus strain VGC1

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag E8M03_RS11255 Protein ID WP_001802298.1
Coordinates 2222935..2223039 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2222776..2222940 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8M03_RS11235 2219013..2219678 - 666 WP_001024088.1 SDR family oxidoreductase -
E8M03_RS11240 2219830..2220150 + 321 WP_000139802.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
E8M03_RS11245 2220152..2221129 + 978 WP_000019732.1 CDF family zinc efflux transporter CzrB -
E8M03_RS11250 2221395..2222486 + 1092 WP_000495695.1 hypothetical protein -
- 2222776..2222940 + 165 - - Antitoxin
E8M03_RS11255 2222935..2223039 - 105 WP_001802298.1 hypothetical protein Toxin
E8M03_RS11260 2223200..2223683 - 484 Protein_2140 recombinase family protein -
E8M03_RS11265 2223726..2224862 - 1137 Protein_2141 SAP domain-containing protein -
E8M03_RS11270 2225151..2225243 + 93 WP_031844941.1 hypothetical protein -
E8M03_RS11275 2225938..2226795 - 858 WP_000370919.1 Cof-type HAD-IIB family hydrolase -
E8M03_RS11280 2226863..2227645 - 783 WP_000908190.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T123966 WP_001802298.1 NZ_CP039448:c2223039-2222935 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T123966 NZ_CP039448:c2223039-2222935 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT123966 NZ_CP039448:2222776-2222940 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References