Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1598640..1599054 Replicon chromosome
Accession NZ_CP039448
Organism Staphylococcus aureus strain VGC1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E8M03_RS07815 Protein ID WP_001065099.1
Coordinates 1598803..1599054 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E8M03_RS14710 Protein ID WP_000028424.1
Coordinates 1598640..1598813 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8M03_RS07760 1594422..1594766 - 345 WP_000402904.1 hypothetical protein -
E8M03_RS07765 1594897..1595196 - 300 WP_000988330.1 HNH endonuclease -
E8M03_RS07770 1595428..1595844 - 417 WP_000590122.1 hypothetical protein -
E8M03_RS07775 1595872..1596072 - 201 WP_000265043.1 DUF1514 family protein -
E8M03_RS07780 1596072..1596722 - 651 WP_001005262.1 hypothetical protein -
E8M03_RS07785 1596881..1597030 - 150 WP_000237868.1 transcriptional activator RinB -
E8M03_RS07790 1597033..1597233 - 201 WP_001125015.1 hypothetical protein -
E8M03_RS07795 1597208..1597396 - 189 WP_000195782.1 DUF1381 domain-containing protein -
E8M03_RS07800 1597393..1597638 - 246 WP_001282074.1 hypothetical protein -
E8M03_RS07805 1597675..1598181 - 507 WP_001061834.1 dUTPase -
E8M03_RS14705 1598196..1598357 - 162 WP_000889683.1 hypothetical protein -
E8M03_RS07810 1598358..1598639 - 282 WP_000454994.1 hypothetical protein -
E8M03_RS14710 1598640..1598813 - 174 WP_000028424.1 hypothetical protein Antitoxin
E8M03_RS07815 1598803..1599054 - 252 WP_001065099.1 DUF1024 family protein Toxin
E8M03_RS07820 1599069..1599311 - 243 WP_000131388.1 phi PVL orf 51-like protein -
E8M03_RS07825 1599315..1599671 - 357 WP_000029366.1 hypothetical protein -
E8M03_RS07830 1599672..1599857 - 186 WP_001187236.1 DUF3113 family protein -
E8M03_RS07835 1599862..1600266 - 405 WP_000049798.1 DUF1064 domain-containing protein -
E8M03_RS07840 1600276..1600497 - 222 WP_001123669.1 DUF3269 family protein -
E8M03_RS07845 1600510..1600668 - 159 WP_000256594.1 hypothetical protein -
E8M03_RS07850 1600662..1601441 - 780 WP_000803062.1 ATP-binding protein -
E8M03_RS07855 1601451..1602221 - 771 WP_000190254.1 conserved phage C-terminal domain-containing protein -
E8M03_RS07860 1602287..1602568 + 282 WP_000414755.1 hypothetical protein -
E8M03_RS14715 1602561..1602710 - 150 WP_001081076.1 hypothetical protein -
E8M03_RS07865 1602707..1603381 - 675 WP_000057262.1 hypothetical protein -
E8M03_RS07870 1603393..1603836 - 444 WP_001099007.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukF-PV / lukS-PV 1571020..1630914 59894


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9376.32 Da        Isoelectric Point: 3.8364

>T123962 WP_001065099.1 NZ_CP039448:c1599054-1598803 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILKGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T123962 NZ_CP039448:c1599054-1598803 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTAAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT123962 WP_000028424.1 NZ_CP039448:c1598813-1598640 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT123962 NZ_CP039448:c1598813-1598640 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References