Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/- |
Location | 1598640..1599054 | Replicon | chromosome |
Accession | NZ_CP039448 | ||
Organism | Staphylococcus aureus strain VGC1 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | E8M03_RS07815 | Protein ID | WP_001065099.1 |
Coordinates | 1598803..1599054 (-) | Length | 84 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | E8M03_RS14710 | Protein ID | WP_000028424.1 |
Coordinates | 1598640..1598813 (-) | Length | 58 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E8M03_RS07760 | 1594422..1594766 | - | 345 | WP_000402904.1 | hypothetical protein | - |
E8M03_RS07765 | 1594897..1595196 | - | 300 | WP_000988330.1 | HNH endonuclease | - |
E8M03_RS07770 | 1595428..1595844 | - | 417 | WP_000590122.1 | hypothetical protein | - |
E8M03_RS07775 | 1595872..1596072 | - | 201 | WP_000265043.1 | DUF1514 family protein | - |
E8M03_RS07780 | 1596072..1596722 | - | 651 | WP_001005262.1 | hypothetical protein | - |
E8M03_RS07785 | 1596881..1597030 | - | 150 | WP_000237868.1 | transcriptional activator RinB | - |
E8M03_RS07790 | 1597033..1597233 | - | 201 | WP_001125015.1 | hypothetical protein | - |
E8M03_RS07795 | 1597208..1597396 | - | 189 | WP_000195782.1 | DUF1381 domain-containing protein | - |
E8M03_RS07800 | 1597393..1597638 | - | 246 | WP_001282074.1 | hypothetical protein | - |
E8M03_RS07805 | 1597675..1598181 | - | 507 | WP_001061834.1 | dUTPase | - |
E8M03_RS14705 | 1598196..1598357 | - | 162 | WP_000889683.1 | hypothetical protein | - |
E8M03_RS07810 | 1598358..1598639 | - | 282 | WP_000454994.1 | hypothetical protein | - |
E8M03_RS14710 | 1598640..1598813 | - | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
E8M03_RS07815 | 1598803..1599054 | - | 252 | WP_001065099.1 | DUF1024 family protein | Toxin |
E8M03_RS07820 | 1599069..1599311 | - | 243 | WP_000131388.1 | phi PVL orf 51-like protein | - |
E8M03_RS07825 | 1599315..1599671 | - | 357 | WP_000029366.1 | hypothetical protein | - |
E8M03_RS07830 | 1599672..1599857 | - | 186 | WP_001187236.1 | DUF3113 family protein | - |
E8M03_RS07835 | 1599862..1600266 | - | 405 | WP_000049798.1 | DUF1064 domain-containing protein | - |
E8M03_RS07840 | 1600276..1600497 | - | 222 | WP_001123669.1 | DUF3269 family protein | - |
E8M03_RS07845 | 1600510..1600668 | - | 159 | WP_000256594.1 | hypothetical protein | - |
E8M03_RS07850 | 1600662..1601441 | - | 780 | WP_000803062.1 | ATP-binding protein | - |
E8M03_RS07855 | 1601451..1602221 | - | 771 | WP_000190254.1 | conserved phage C-terminal domain-containing protein | - |
E8M03_RS07860 | 1602287..1602568 | + | 282 | WP_000414755.1 | hypothetical protein | - |
E8M03_RS14715 | 1602561..1602710 | - | 150 | WP_001081076.1 | hypothetical protein | - |
E8M03_RS07865 | 1602707..1603381 | - | 675 | WP_000057262.1 | hypothetical protein | - |
E8M03_RS07870 | 1603393..1603836 | - | 444 | WP_001099007.1 | single-stranded DNA-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | lukF-PV / lukS-PV | 1571020..1630914 | 59894 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9376.32 Da Isoelectric Point: 3.8364
>T123962 WP_001065099.1 NZ_CP039448:c1599054-1598803 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILKGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILKGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T123962 NZ_CP039448:c1599054-1598803 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTAAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTAAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT123962 WP_000028424.1 NZ_CP039448:c1598813-1598640 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT123962 NZ_CP039448:c1598813-1598640 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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