Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 900501..900915 Replicon chromosome
Accession NZ_CP039448
Organism Staphylococcus aureus strain VGC1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E8M03_RS04470 Protein ID WP_001065064.1
Coordinates 900501..900752 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E8M03_RS14680 Protein ID WP_000028424.1
Coordinates 900742..900915 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8M03_RS04425 895616..896290 + 675 WP_031769015.1 phi PV83 orf 19-like protein -
E8M03_RS04430 896396..897253 - 858 WP_000371250.1 DUF4393 domain-containing protein -
E8M03_RS04435 897318..898088 + 771 WP_031769013.1 conserved phage C-terminal domain-containing protein -
E8M03_RS04440 898098..898871 + 774 WP_031769012.1 ATP-binding protein -
E8M03_RS14675 898865..899026 + 162 WP_000237153.1 hypothetical protein -
E8M03_RS04445 899039..899260 + 222 WP_001123673.1 DUF3269 family protein -
E8M03_RS04450 899271..899675 + 405 WP_000049784.1 DUF1064 domain-containing protein -
E8M03_RS04455 899680..899865 + 186 WP_001187242.1 DUF3113 family protein -
E8M03_RS04460 899866..900237 + 372 WP_001140289.1 hypothetical protein -
E8M03_RS04465 900238..900486 + 249 WP_001126846.1 phi PVL orf 51-like protein -
E8M03_RS04470 900501..900752 + 252 WP_001065064.1 DUF1024 family protein Toxin
E8M03_RS14680 900742..900915 + 174 WP_000028424.1 hypothetical protein Antitoxin
E8M03_RS14685 900916..901077 + 162 WP_000889680.1 hypothetical protein -
E8M03_RS04475 901092..901619 + 528 WP_149569683.1 dUTPase -
E8M03_RS04480 901656..901862 + 207 WP_029625633.1 DUF1381 domain-containing protein -
E8M03_RS04485 901859..902032 + 174 WP_149569684.1 transcriptional activator RinB -
E8M03_RS04490 902033..902434 + 402 WP_000286968.1 hypothetical protein -
E8M03_RS04500 902789..903283 + 495 WP_000594088.1 terminase small subunit -
E8M03_RS04505 903276..904499 + 1224 WP_001037578.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq / seb 845250..934685 89435


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.26 Da        Isoelectric Point: 3.7128

>T123961 WP_001065064.1 NZ_CP039448:900501-900752 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T123961 NZ_CP039448:900501-900752 [Staphylococcus aureus]
ATGAATAATCGTGAACAAATTGAACAATCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGACAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT123961 WP_000028424.1 NZ_CP039448:900742-900915 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT123961 NZ_CP039448:900742-900915 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAATCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References