Detailed information of TA system TA123938

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2605421..2605757
• Replicon: chromosome
• Accession: NZ_CP039434
• Organism: Enterococcus faecalis strain SGAir0397

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: E7T04_RS13170
• Protein ID: WP_033628601.1
• Coordinates: 2605421..2605564 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2605496..2605757 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E7T04_RS13145	2601075..2601707	-	633	WP_002358972.1	RloB family protein	-
E7T04_RS13150	2601716..2603011	-	1296	WP_002410675.1	AAA family ATPase	-
E7T04_RS13165	2603473..2605089	+	1617	WP_137685830.1	phosphatase PAP2/LCP family protein	-
E7T04_RS13170	2605421..2605564	+	144	WP_033628601.1	putative holin-like toxin	Toxin
-	2605496..2605757	-	262	NuclAT_4	-	Antitoxin
E7T04_RS13180	2605758..2609702	-	3945	WP_137685831.1	WxL domain-containing protein	-
E7T04_RS13185	2609689..2610051	-	363	WP_010776206.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5217.26 Da
• Isoelectric Point: 9.9304

>T123938 WP_033628601.1 NZ_CP039434:2605421-2605564 [Enterococcus faecalis]
MNVSTEIYERRGLLSIAEALALMISFGSFIATLIFGILKAVKEDKKK

Nucleotide

• Length: 144 bp

>T123938 NZ_CP039434:2605421-2605564 [Enterococcus faecalis]
ATGAATGTAAGTACTGAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAAAAGCTGTTAAAGAAGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 262 bp

>AT123938 NZ_CP039434:c2605757-2605496 [Enterococcus faecalis]
AAATAAAAGATGCCCGAGCCTTGAAATAGGAGGCTCGGGCATCTTTTATTGATGGTCTTTTTAGGGGCGTTGTGCTATAA
TGGTAATGAGAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATTT
ATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTCTTGTCTTCTTTAACAGCTTTTAGGATTCCGAAGATTA
ACGTTGCGATAAAAGAACCGAA

Structures

Antitoxin