Detailed information of TA system TA123935

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2530292..2530552
• Replicon: chromosome
• Accession: NZ_CP039434
• Organism: Enterococcus faecalis strain SGAir0397

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: E7T04_RS12805
• Protein ID: WP_002392696.1
• Coordinates: 2530409..2530552 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2530292..2530476 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E7T04_RS12790	2525705..2528449	+	2745	WP_137685823.1	glycoside hydrolase family 65 protein	-
E7T04_RS12795	2528464..2529114	+	651	WP_137685824.1	beta-phosphoglucomutase	-
E7T04_RS12800	2529576..2530169	+	594	WP_175404155.1	hypothetical protein	-
-	2530292..2530476	+	185	NuclAT_7	-	Antitoxin
E7T04_RS12805	2530409..2530552	-	144	WP_002392696.1	putative holin-like toxin	Toxin
E7T04_RS12810	2530784..2531755	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
E7T04_RS12815	2531930..2532367	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
E7T04_RS12820	2532499..2533053	-	555	WP_002354869.1	septum formation protein Maf	-
E7T04_RS12825	2533078..2535210	-	2133	WP_010713705.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T123935 WP_002392696.1 NZ_CP039434:c2530552-2530409 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T123935 NZ_CP039434:c2530552-2530409 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATCGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 185 bp

>AT123935 NZ_CP039434:2530292-2530476 [Enterococcus faecalis]
TGCTATAATAAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCAATTTA
GTTATAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCGCG
ATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin