Detailed information of TA system TA123902

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA(toxin)
• Location: 4492415..4493733
• Replicon: chromosome
• Accession: NZ_CP039403
• Organism: Escherichia coli strain 382634_2f

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: E4311_RS22170
• Protein ID: WP_021560080.1
• Coordinates: 4492415..4493422 (-)
• Length: 336 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: A0A2A7M399
• Locus tag: E4311_RS22175
• Protein ID: WP_001490601.1
• Coordinates: 4493422..4493733 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4311_RS22135	4488108..4488299	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
E4311_RS22140	4488296..4489975	+	1680	WP_021560079.1	cellulose biosynthesis protein BcsG	-
E4311_RS22145	4490061..4490168	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	4490217..4490282	+	66	NuclAT_24	-	-
-	4490217..4490282	+	66	NuclAT_24	-	-
-	4490217..4490282	+	66	NuclAT_24	-	-
-	4490217..4490282	+	66	NuclAT_24	-	-
E4311_RS22155	4490544..4490651	-	108	WP_000170747.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	4490700..4490765	+	66	NuclAT_25	-	-
-	4490700..4490765	+	66	NuclAT_25	-	-
-	4490700..4490765	+	66	NuclAT_25	-	-
-	4490700..4490765	+	66	NuclAT_25	-	-
E4311_RS22165	4491127..4492398	+	1272	WP_001312176.1	amino acid permease	-
E4311_RS22170	4492415..4493422	-	1008	WP_021560080.1	HipA domain-containing protein	Toxin
E4311_RS22175	4493422..4493733	-	312	WP_001490601.1	HipA N-terminal domain-containing protein	Antitoxin
E4311_RS22180	4493718..4494041	-	324	WP_021560081.1	helix-turn-helix transcriptional regulator	-
E4311_RS22185	4494266..4495279	-	1014	WP_001357946.1	dipeptide ABC transporter ATP-binding subunit DppF	-
E4311_RS22190	4495276..4496259	-	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
E4311_RS22195	4496270..4497172	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
E4311_RS22200	4497182..4498201	-	1020	WP_000938855.1	dipeptide ABC transporter permease DppB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (56-302)

Antitoxin

• HipA, N-terminal subdomain 1 (6-98)

Sequences

Toxin

Protein

• Length: 336 a.a.
• Molecular weight: 38395.65 Da
• Isoelectric Point: 5.4135

>T123902 WP_021560080.1 NZ_CP039403:c4493422-4492415 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDYKGLPVHQEQLDGAMQITD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPTLAPVYDFVSVAPY
PEYFYSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Nucleotide

• Length: 1008 bp

>T123902 NZ_CP039403:c4493422-4492415 [Escherichia coli]
ATGGCGAATTGTCGTATTCTGTTAACGCCGTTGAATGAACGTGACGAACAGCGCGGATATTCGACACAGGGGTTGAAGCG
ACTGAGCGGCACTGCAAAATTGACCCCCAGGCTGGGGTTTACGCGAACTCAGTTTGTGCAGGAACTTCCGCGTCAACAAA
AAGGGATGAGTATTTCCGGTTACCAGCCCAAATTGCAATTAGTGCTGGATGAAGGAGAGTTCCGCGTCGTAGATCATCAG
GGAAATTTTATCCTTAAGCCCTCTCCAGCCGACTTTCCCGGCTTGGCCGAAAATGAACACGCAACAATGACATTGATGTC
TCGTTTGGGATTTGACGTACCTGTGCATGGCCTGTTGAGTTTTGCACCACAATCAGAGGAAGAGCTTGAATACGCATTTG
TTATCCGGCGCTATGACCGGGATTACAAGGGGCTGCCAGTGCATCAGGAACAGCTTGATGGCGCGATGCAGATTACAGAT
AAATATGGCAAAACGGGGAATGATAACGAACAATATGTCAGCTATGAAACGCTGGCCCGATTTTTAGTTGCCCATGTTAA
CGACAACATCGCATTTAAAATCGATCTCTTTCGTCGCATTGTTTACGCCTGGTTGCTGGGTAATAACGACATGCATTTAC
GAAACTTTGGTTTAGTGTACTCCGATGGTTTGACGCCAACGTTAGCGCCGGTGTATGACTTTGTTTCTGTCGCTCCCTAT
CCGGAATATTTTTACTCAAACTATCTGGCGCTGCCGTTATTGACGCGAGAAGAAGGCGGTCGGGAACTGGCTCCTGGATT
TCACAGTGATTATGGCGAGTATATCGGGCAGGACTTTTTGCTGTTGGGTGAATCAATGGGGTTAGCGCCCAGATTGCTGG
AAAAACTCTTTCAGGATATACGTAAAGAAAATGCCATTGTTATGGAAACGTATGAGCAGTCCTTTATGACTCAGGATCAT
ATCCAGGCTGTGCTGCAATGCTATCGACATCGTCTGGGGCTGCTGTGA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11822.40 Da
• Isoelectric Point: 6.0609

>AT123902 WP_001490601.1 NZ_CP039403:c4493733-4493422 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAQDYHGPAISISLPVAQRQFPSETLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Nucleotide

• Length: 312 bp

>AT123902 NZ_CP039403:c4493733-4493422 [Escherichia coli]
ATGCATCGACGAGTGAAAGTGTTGCTCTATGGTCAGGTAGTGGGTGAACTCTCTCAGAACGACAGTGGTTTTTTGTTCCA
GTACGCCCAGGATTACCACGGACCGGCAATCTCAATCAGCCTGCCCGTCGCACAGCGTCAGTTTCCCAGTGAGACGTTGC
ATCCTTATTTCGCCTCACTGGCGCCAGAAGGATGGCTGCGTCAACGCTACAGCCAGATACAGCATCGTGACGAAAACGAT
CTGCTGGGAATGCTTATTGATAACGGCAAGAATCTGCTGGGGGCAATCCAGATTTTACCTTGGGAGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A2A7M399