Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4711601..4712261 Replicon chromosome
Accession NZ_CP039388
Organism Enterobacter hormaechei strain cre64

Toxin (Protein)


Gene name higB Uniprot ID A0A2J0Q4X0
Locus tag EZJ11_RS22945 Protein ID WP_017383312.1
Coordinates 4711908..4712261 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0Q4Z7
Locus tag EZJ11_RS22940 Protein ID WP_017383313.1
Coordinates 4711601..4711903 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EZJ11_RS22925 (EZJ11_23210) 4707775..4709100 + 1326 WP_032619371.1 SidA/IucD/PvdA family monooxygenase -
EZJ11_RS22930 (EZJ11_23215) 4709127..4711316 + 2190 WP_023303946.1 TonB-dependent siderophore receptor -
EZJ11_RS22940 (EZJ11_23225) 4711601..4711903 - 303 WP_017383313.1 XRE family transcriptional regulator Antitoxin
EZJ11_RS22945 (EZJ11_23230) 4711908..4712261 - 354 WP_017383312.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EZJ11_RS22950 (EZJ11_23235) 4712452..4713402 - 951 WP_032619370.1 HTH-type transcriptional regulator Cbl -
EZJ11_RS22955 (EZJ11_23240) 4713499..4714416 - 918 WP_003859531.1 nitrogen assimilation transcriptional regulator NAC -
EZJ11_RS22965 (EZJ11_23250) 4714948..4715880 - 933 WP_023303950.1 L,D-transpeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13537.37 Da        Isoelectric Point: 9.9538

>T123872 WP_017383312.1 NZ_CP039388:c4712261-4711908 [Enterobacter hormaechei]
VWAIKTTDRFDDWFTSLNDSERASVLAALLVLRERGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
VLCAGNKVGNERRFYDEMLLVADREYTRWLNTLKERN

Download         Length: 354 bp

>T123872 NZ_CP039388:c4712261-4711908 [Enterobacter hormaechei]
GTGTGGGCGATTAAAACTACGGACAGGTTTGACGACTGGTTCACCTCATTAAACGATAGCGAGAGAGCCAGCGTACTGGC
CGCGCTACTTGTTTTGCGGGAGAGGGGACCGGGTCTGTCCAGACCGTATGCCGATACGCTGAAAGGCTCCCGCCACAGCA
ACATGAAAGAGTTGCGTATCCAGAGTAAGGGTGATCCGCTGAGGGCATTTTTCGCTTTCGATCCGAACCGTACGGGTATT
GTACTGTGTGCGGGCAATAAGGTCGGTAATGAAAGGCGATTTTACGATGAGATGCTCCTCGTTGCGGATCGGGAATACAC
TCGCTGGCTGAACACATTAAAAGAGAGGAATTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11028.85 Da        Isoelectric Point: 6.4727

>AT123872 WP_017383313.1 NZ_CP039388:c4711903-4711601 [Enterobacter hormaechei]
MGRTLEQLIADEKPEVVASAQAMATDILLNIHLAELREKVQKTQVDMARALGIKQPTVAVMEKAGRDIKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT123872 NZ_CP039388:c4711903-4711601 [Enterobacter hormaechei]
ATGGGCAGAACCCTGGAGCAGCTTATTGCAGATGAAAAACCTGAGGTTGTTGCCAGCGCACAGGCAATGGCAACGGATAT
TTTGCTCAATATCCATCTGGCCGAGTTACGTGAAAAAGTGCAAAAAACGCAGGTAGATATGGCCAGGGCGTTGGGTATTA
AACAACCTACTGTCGCCGTCATGGAAAAGGCAGGACGCGATATTAAGCTTTCTTCTTTGAAACGCTACGTTGAGGCCGCC
GGAGGGAAGCTACGGCTGGATGTAGAACTACCCGATGGTTCTCATTACGAGTTTGTGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0Q4X0

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0Q4Z7

References