Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 752058..752634 Replicon chromosome
Accession NZ_CP039374
Organism Halomonas titanicae strain ANRCS81

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E8A47_RS03490 Protein ID WP_141439976.1
Coordinates 752058..752336 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag E8A47_RS03495 Protein ID WP_022520034.1
Coordinates 752347..752634 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8A47_RS03465 747351..748196 + 846 WP_141439980.1 EamA family transporter -
E8A47_RS03470 748600..749454 + 855 WP_141439979.1 Dimeric alpha-beta barrel -
E8A47_RS03475 749526..750224 + 699 WP_141439978.1 class I SAM-dependent methyltransferase -
E8A47_RS03480 750335..750741 + 407 Protein_676 GFA family protein -
E8A47_RS03485 750986..751948 + 963 WP_141439977.1 ribonuclease Z -
E8A47_RS03490 752058..752336 + 279 WP_141439976.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E8A47_RS03495 752347..752634 + 288 WP_022520034.1 HigA family addiction module antidote protein Antitoxin
E8A47_RS03500 752741..753160 - 420 WP_141439975.1 hypothetical protein -
E8A47_RS03505 753708..754229 - 522 WP_027957389.1 NAD(P)H-dependent oxidoreductase -
E8A47_RS03510 754894..755547 + 654 WP_041157596.1 DsbA family oxidoreductase -
E8A47_RS03515 755647..756840 - 1194 WP_141439974.1 homoserine O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-86)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10332.76 Da        Isoelectric Point: 10.3742

>T123845 WP_141439976.1 NZ_CP039374:752058-752336 [Halomonas titanicae]
MIRSFKHKGLAKFFKSGSTAGIQAAHAKRLRLILGRLNAVSDANDMDLPGLRLHELSGKRSGIWSVTVSGNWRVTFRFED
GDAEIVNYEDYH

Download         Length: 279 bp

>T123845 NZ_CP039374:752058-752336 [Halomonas titanicae]
ATGATCCGAAGCTTCAAACACAAAGGCTTGGCAAAATTCTTCAAATCCGGCAGCACTGCAGGGATTCAGGCTGCGCATGC
AAAGAGGCTTCGGCTTATTCTTGGTCGACTTAATGCAGTGTCAGATGCCAACGATATGGACTTGCCAGGTCTTCGCTTGC
ACGAACTCTCAGGTAAGCGCTCTGGAATCTGGTCAGTCACGGTTAGTGGTAACTGGCGCGTGACGTTCCGGTTCGAGGAC
GGAGATGCCGAGATAGTGAATTATGAAGATTACCACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10442.08 Da        Isoelectric Point: 7.3596

>AT123845 WP_022520034.1 NZ_CP039374:752347-752634 [Halomonas titanicae]
MLMHNPPHPGEVLRELCLEPLGLTVTAAAEALGVSRKTLSAVLNGKAGISPEMAVRLSIAFDTSAESWLNQQSQYELWHA
EQHRKELKVKRLVAA

Download         Length: 288 bp

>AT123845 NZ_CP039374:752347-752634 [Halomonas titanicae]
ATGCTGATGCACAACCCTCCCCATCCTGGTGAAGTATTACGCGAGCTTTGCTTGGAGCCCCTTGGCCTTACTGTTACAGC
CGCTGCGGAAGCGCTCGGCGTAAGTCGCAAAACGCTCAGTGCTGTGCTGAACGGCAAGGCCGGTATTAGCCCTGAAATGG
CGGTGCGGCTTTCTATCGCGTTTGATACCTCTGCGGAAAGCTGGTTGAACCAGCAGTCCCAATACGAGCTTTGGCATGCC
GAACAGCATCGCAAAGAGCTTAAAGTAAAGAGGCTGGTTGCCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References