Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4833401..4834000 Replicon chromosome
Accession NZ_CP039327
Organism Citrobacter portucalensis strain Effluent_1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E7703_RS23695 Protein ID WP_048227551.1
Coordinates 4833689..4834000 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E7703_RS23690 Protein ID WP_038635893.1
Coordinates 4833401..4833688 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E7703_RS23675 4830897..4831799 + 903 WP_003825273.1 formate dehydrogenase O subunit beta -
E7703_RS23680 4831796..4832431 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
E7703_RS23685 4832428..4833357 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
E7703_RS23690 4833401..4833688 - 288 WP_038635893.1 helix-turn-helix domain-containing protein Antitoxin
E7703_RS23695 4833689..4834000 - 312 WP_048227551.1 hypothetical protein Toxin
E7703_RS23700 4834221..4835129 + 909 WP_136392454.1 alpha/beta hydrolase -
E7703_RS23705 4835194..4835436 + 243 WP_136392455.1 type II toxin-antitoxin system ParD family antitoxin -
E7703_RS23710 4835429..4835716 + 288 WP_136392456.1 type II toxin-antitoxin system RelE/ParE family toxin -
E7703_RS23715 4835722..4836663 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
E7703_RS23720 4836708..4837145 - 438 WP_003825289.1 D-tyrosyl-tRNA(Tyr) deacylase -
E7703_RS23725 4837142..4838014 - 873 WP_079935075.1 virulence factor BrkB family protein -
E7703_RS23730 4838008..4838607 - 600 WP_008786997.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-74)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12390.54 Da        Isoelectric Point: 10.2893

>T123816 WP_048227551.1 NZ_CP039327:c4834000-4833689 [Citrobacter portucalensis]
MLFIETEIFTEDVKKLLDDDEYRRLQIFLAIQPDCGDLIQETGGLRKVRWRSRGKGKRSGVRIIYFHQIRKSQIRLLLIY
QKGIKDDLTPQEKVLLRMLNERW

Download         Length: 312 bp

>T123816 NZ_CP039327:c4834000-4833689 [Citrobacter portucalensis]
ATGCTATTCATAGAAACGGAAATCTTCACTGAAGACGTCAAAAAATTACTGGATGATGATGAATACCGCAGATTACAGAT
ATTCCTTGCGATTCAGCCTGATTGTGGCGATCTGATACAAGAAACGGGCGGACTGAGAAAGGTTCGCTGGAGATCGCGAG
GGAAAGGCAAACGTAGCGGTGTGAGGATTATTTACTTTCATCAAATCAGAAAATCACAAATTCGATTGTTGCTGATTTAT
CAGAAAGGGATCAAGGATGATCTGACTCCACAAGAAAAAGTGCTGCTGCGTATGTTGAATGAGAGGTGGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10761.36 Da        Isoelectric Point: 11.1842

>AT123816 WP_038635893.1 NZ_CP039327:c4833688-4833401 [Citrobacter portucalensis]
MDKALFERLTQSMVQMNEIAEGTRQPSRTFHIDAMKIKEIRQSSGLSQTRFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPKHVIQALR

Download         Length: 288 bp

>AT123816 NZ_CP039327:c4833688-4833401 [Citrobacter portucalensis]
ATGGATAAGGCACTATTTGAGCGATTAACTCAAAGTATGGTTCAGATGAATGAGATCGCTGAAGGAACGCGACAACCTTC
CCGTACCTTTCATATTGACGCCATGAAAATAAAGGAAATTCGCCAGTCTTCAGGATTATCACAGACTCGTTTCGCAGATT
TGATATCGGTAAGCGTGGATACGTTGCGAAATTGGGAGCAAGGGCGTCGTTCACCGACCGGTCCAGCAAAAGCGTTGTTA
CGTGCTATTGCCAATGATCCAAAACATGTCATTCAGGCACTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References